Trial reportEuropean journal of clinical nutrition2002
Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study.
Trial report in European journal of clinical nutrition, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of alcohol on blood pressure.The Cochrane database of systematic reviews · 2020Pooled it
- To beer or not to beer: A meta-analysis of the effects of beer consumption on cardiovascular health.PloS one · 2020Pooled it
- Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies.BMJ (Clinical research ed.) · 2011Pooled it
- Trial
- The effect of moderate alcohol consumption on biomarkers of inflammation and hemostatic factors in postmenopausal women.European journal of clinical nutrition · 2016Trial
- Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Trial
- Smoking and severity of hepatic fibrosis in nonalcoholic fatty liver disease.Journal of hepatology · 2011Trial
- Alcohol consumption and risk of cardiovascular disease and death in women: potential mediating mechanisms.Circulation · 2009Trial
- Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis.European journal of clinical nutrition · 2006Trial
- Intake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjects.European journal of clinical nutrition · 2004Trial
- Prevalence of and risk factors for diabetic retinopathy: The Thessaloniki Eye Study.Eye (London, England) · 2026Article
- Alcohol Consumption Patterns and Traditional Beverages Associated with Hypertension Subtypes.Medical sciences (Basel, Switzerland) · 2026Article
- Associations of alcohol drinking with incident dementia: a prospective study from the UK Biobank.European journal of epidemiology · 2025Observational
- Alcohol consumption and immune cell profiles: Insights from the Framingham Heart Study.Alcohol, clinical & experimental research · 2025Article
- Effects of Moderate Consumption of a Probiotic-Fermented Sour Beer on the Inflammatory, Immunity, Lipid Profile, and Gut Microbiome of Healthy Men in a Participant-Blinded, Randomized-Controlled Within-Subject Crossover Study.Food science & nutrition · 2024Article
- Dietary Inflammatory Index and risk of breast cancer: evidence from a prospective cohort of 67,879 women followed for 20 years in France.European journal of nutrition · 2023Article
- Beer-gut microbiome alliance: a discussion of beer-mediated immunomodulation via the gut microbiome.Frontiers in nutrition · 2023Review
- Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.European journal of nutrition · 2022Article
- Effect of Beer Consumption on Methylation and Redox Metabolism.Physiological research · 2022Article
- Alcohol, Drinking Pattern, and Chronic Disease.Nutrients · 2022Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen.
designRandomized, diet-controlled, cross-over study.
settingThe study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands. SUBJECTS: Ten middle-aged men and 10 postmenopausal women, all apparently healthy, non-smoking and moderate alcohol drinkers, were included. One women dropped out because of a treatment-unrelated cause. The remaining 19 subjects finished the experiment successfully.
interventionsMen consumed four glasses and women consumed three glasses of beer or no-alcohol beer (control) with evening dinner during two successive periods of 3 weeks. The total diet was supplied to the subjects and had essentially the same composition during these 6 weeks. Before each treatment there was a 1 week washout period to compensate for possible carry-over effects.
resultsPlasma C-reactive protein and fibrinogen levels were decreased by 35% (P=0.02) and 12.4% (P< or =0.001), respectively, after 3 weeks' consumption of beer, as compared to no-alcohol beer consumption.
conclusionsModerate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. An anti-inflammatory action of alcohol may help explain the link between moderate alcohol consumption and lower cardiovascular disease risk. SPONSORSHIP: Dutch Foundation for Alcohol Research (SAR).
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.