ArticleThe Journal of cell biology2002
EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Myoepithelial progenitors as founder cells of hyperplastic human breast lesions upon PIK3CA transformation.Communications biology · 2022Article
- Real-time imaging of integrin β4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing.Journal of cell science · 2019Article
- Proof of region-specific multipotent progenitors in human breast epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes.Oncotarget · 2015Article
- Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding.Journal of neuroinflammation · 2012Article
- Triple-negative breast cancer: disease entity or title of convenience?Nature reviews. Clinical oncology · 2010Review
- Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells.Cancer research · 2009Article
- [Anatomy of the breast].Der Pathologe · 2009Review
- Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells.Nature cell biology · 2008Article
- Mammary glands and feathers: comparing two skin appendages which help define novel classes during vertebrate evolution.Seminars in cell & developmental biology · 2007Review
- Laminin alpha2 chain-positive vessels and epidermal growth factor in lung neuroendocrine carcinoma: a model of a novel cooperative role of laminin-2 and epidermal growth factor in vessel neoplastic invasion and metastasis.The American journal of pathology · 2006Article
- Maintenance of cell type diversification in the human breast.Journal of mammary gland biology and neoplasia · 2005Review
- Integrins in mammary gland development and differentiation of mammary epithelium.Journal of mammary gland biology and neoplasia · 2003Review
- Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept.Cell proliferation · 2003Review
- Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia.Cell proliferation · 2003Review
- Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development.Breast cancer research : BCR · 2003Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bilayered mammary epithelium comprises a luminal layer of secretory cells and a basal layer of myoepithelial cells. Numerous data suggest the existence of self-renewing, pluripotent mammary stem cells; however, their molecular characteristics and differentiation pathways are largely unknown. BC44 mammary epithelial cells in culture, display phenotypic characteristics of basal epithelium, i.e., express basal cytokeratins 5 and 14 and P-cadherin, but no smooth muscle markers. In vivo, after injection into the cleared mammary fat pad, these cells gave rise to bilayered, hollow, alveolus-like structures comprising basal cells expressing cytokeratin 5 and luminal cells positive for cytokeratin 8 and secreting beta-casein in a polarized manner into the lumen. The persistent stimulation of EGF receptor signaling pathway in BC44 cells in culture resulted in the loss of the in vivo morphogenetic potential and led to the induction of active MMP2, thereby triggering cell scattering and motility on laminin 5. These data (a) suggest that BC44 cells are capable of asymmetric division for self-renewal and the generation of a differentiated progeny restricted to the luminal lineage; (b) clarify the function of EGF in the control of the BC44 cell phenotypic plasticity; and (c) suggest a role for this phenomenon in the mammary gland development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.