ArticleThe Journal of cell biology2002
Signal recognition particle RNA localization within the nucleolus differs from the classical sites of ribosome synthesis.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Granular component sub-phases direct ribosome biogenesis in the nucleolus.Molecular cell · 2026Article
- The nucleolar phase of signal recognition particle assembly.Life science alliance · 2024Article
- SRPassing Co-translational Targeting: The Role of the Signal Recognition Particle in Protein Targeting and mRNA Protection.International journal of molecular sciences · 2021Review
- Article
- Fanconi anemia protein FANCI functions in ribosome biogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways.Histochemistry and cell biology · 2016Review
- Exportin-5 mediates nuclear export of SRP RNA in vertebrates.Genes to cells : devoted to molecular & cellular mechanisms · 2015Article
- DNA damage: a sensible mediator of the differentiation decision in hematopoietic stem cells and in leukemia.International journal of molecular sciences · 2015Review
- The nucleolus stress response is coupled to an ATR-Chk1-mediated G2 arrest.Molecular biology of the cell · 2013Article
- NC-mediated nucleolar localization of retroviral gag proteins.Virus research · 2013Article
- A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.The Journal of biological chemistry · 2012Article
- Distribution and localization of fibroblast growth factor-8 in rat brain and nerve cells during neural stem/progenitor cell differentiation.Neural regeneration research · 2012Article
- The nucleus introduced.Cold Spring Harbor perspectives in biology · 2011Review
- The nucleolus.Cold Spring Harbor perspectives in biology · 2011Review
- MicroRNAs with a nucleolar location.RNA (New York, N.Y.) · 2009Article
- Nucleolus: the fascinating nuclear body.Histochemistry and cell biology · 2008Review
- Multiple controls regulate nucleostemin partitioning between nucleolus and nucleoplasm.Journal of cell science · 2006Article
- MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- The nucleolus: a model for the organization of nuclear functions.Histochemistry and cell biology · 2006Review
- Spatial organization of transcription by RNA polymerase III.Nucleic acids research · 2006Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The nucleolus is the site of ribosome biosynthesis, but is now known to have other functions as well. In the present study we have investigated how the distribution of signal recognition particle (SRP) RNA within the nucleolus relates to the known sites of ribosomal RNA synthesis, processing, and nascent ribosome assembly (i.e., the fibrillar centers, the dense fibrillar component (DFC), and the granular component). Very little SRP RNA was detected in fibrillar centers or the DFC of the nucleolus, as defined by the RNA polymerase I-specific upstream binding factor and the protein fibrillarin, respectively. Some SRP RNA was present in the granular component, as marked by the protein B23, indicating a possible interaction with ribosomal subunits at a later stage of maturation. However, a substantial portion of SRP RNA was also detected in regions of the nucleolus where neither B23, UBF, or fibrillarin were concentrated. Dual probe in situ hybridization experiments confirmed that a significant fraction of nucleolar SRP RNA was not spatially coincident with 28S ribosomal RNA. These results demonstrate that SRP RNA concentrates in an intranucleolar location other than the classical stations of ribosome biosynthesis, suggesting that there may be nucleolar regions that are specialized for other functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.