ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Expression and physiological actions of cholecystokinin in rat taste receptor cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 122 citations in OpenAlex.
- Neuropeptide Y and peptide YY differentially modulate bitter- and fatty acid-evoked responses in human fungiform taste bud cells.American journal of physiology. Cell physiology · 2026Article
- Mechanisms of postoperative anorexia in surgical patients: a narrative review.Frontiers in neuroscience · 2026Review
- Endocrinology of Taste with Aging.Endocrinology and metabolism clinics of North America · 2023Review
- [Mechanisms and Management of COVID-19-Associated Taste Disorders].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- Administration of Exendin-4 but not CCK alters lick responses and trial initiation to sucrose and intralipid during brief-access tests.Chemical senses · 2022Article
- Y1 receptors modulate taste-related behavioral responsiveness in male mice to prototypical gustatory stimuli.Hormones and behavior · 2021Article
- Do Gut Microbes Taste?Nutrients · 2021Review
- Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020.Endocrinology and metabolism (Seoul, Korea) · 2021Review
- Recent Advances in Neural Circuits for Taste Perception in Hunger.Frontiers in neural circuits · 2021Review
- An alternative pathway for sweet sensation: possible mechanisms and physiological relevance.Pflugers Archiv : European journal of physiology · 2020Review
- Consequences of Obesity on the Sense of Taste: Taste Buds as Treatment Targets?Diabetes & metabolism journal · 2020Review
- Proceedings of the 2015 ASPEN Research Workshop-Taste Signaling.JPEN. Journal of parenteral and enteral nutrition · 2017Article
- The Role of Cholecystokinin in Peripheral Taste Signaling in Mice.Frontiers in physiology · 2017Article
- Selective expression of muscarinic acetylcholine receptor subtype M3 by mouse type III taste bud cells.Pflugers Archiv : European journal of physiology · 2016Article
- Metabolic effects of non-nutritive sweeteners.Physiology & behavior · 2015Review
- Glucagon-like peptide-1 is specifically involved in sweet taste transmission.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Taste responsiveness to sweeteners is resistant to elevations in plasma leptin.Chemical senses · 2015Article
- The endocrinology of taste receptors.Nature reviews. Endocrinology · 2015Review
- Taste perception, associated hormonal modulation, and nutrient intake.Nutrition reviews · 2015Review
- Ingestion of bacterial lipopolysaccharide inhibits peripheral taste responses to sucrose in mice.Neuroscience · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Gustatory perception arises not only from intracellular transduction cascades within taste receptor cells but also from cell-to-cell communication among the cells of the taste bud. This study presents novel data demonstrating that the brain-gut peptide cholecystokinin (CCK) is expressed in subsets of taste receptor cells, and that it may play a signaling role unknown previously within the taste bud. Immunocytochemistry revealed positively stained subsets of cells within taste buds throughout the oral cavity. These cells typically displayed round nuclei with full processes, similar to those classified as light cells. Peptide expression was verified using nested PCR on template cDNA derived from mRNA extracted from isolated posterior taste buds. Multiple physiological actions of cholecystokinin on taste receptor cells were observed. An outward potassium current, recorded with the patch-clamp technique, was inhibited by exogenous application of sulfated cholecystokinin octapeptide in a reversible and concentration-dependent manner. Pharmacological analysis suggests that this inhibition is mediated by CCK-A receptors and involves PKC phosphorylation. An inwardly rectifying potassium current, typically invariant to stimulation, was also inhibited by cholecystokinin. Additionally, exogenous cholecystokinin was effective in elevating intracellular calcium as measured by ratiometric techniques with the calcium-sensitive dye fura-2. Pharmacology similarly demonstrated that these calcium elevations were mediated by CCK-A receptors and were dependent on intracellular calcium stores. Collectively, these observations suggest a newly discovered role for peptide neuromodulation in the peripheral processing of taste information.
Indexed as
Identifiers
12427859PMC6757850W1539768174What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.