ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Inverse relationship between release probability and readily releasable vesicles in depressing and facilitating synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed.
- Molecular Logic of Synaptic Diversity BetweenbioRxiv : the preprint server for biology · 2023Article
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- The functional properties of synapses made by regenerated axons across spinal cord lesion sites in lamprey.Neural regeneration research · 2022Article
- The glutamatergic synapse: a complex machinery for information processing.Cognitive neurodynamics · 2021Review
- Secreted C-type lectin regulation of neuromuscular junction synaptic vesicle dynamics modulates coordinated movement.Journal of cell science · 2021Article
- Synaptic Properties and Plasticity Mechanisms of Invertebrate Tonic and Phasic Neurons.Frontiers in physiology · 2020Review
- Target-wide Induction and Synapse Type-Specific Robustness of Presynaptic Homeostasis.Current biology : CB · 2019Article
- Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.Nature communications · 2017Article
- A Gradient in Synaptic Strength and Plasticity among Motoneurons Provides a Peripheral Mechanism for Locomotor Control.Current biology : CB · 2017Article
- VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3.Frontiers in cellular neuroscience · 2017Article
- Membrane-derived phospholipids control synaptic neurotransmission and plasticity.PLoS biology · 2015Article
- Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses.Neural plasticity · 2015Article
- SNARE zippering and synaptic strength.PloS one · 2014Article
- Mechanical properties of respiratory muscles.Comprehensive Physiology · 2013Review
- GABAB receptor-mediated frequency-dependent and circadian changes in synaptic plasticity modulate retinal input to the suprachiasmatic nucleus.The Journal of physiology · 2013Article
- Article
- LIS1 deficiency promotes dysfunctional synaptic integration of granule cells generated in the developing and adult dentate gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Endogenous Rho-kinase signaling maintains synaptic strength by stabilizing the size of the readily releasable pool of synaptic vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Physiological recordings of high and low output NMJs on the crayfish leg extensor muscle.Journal of visualized experiments : JoVE · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We tested the hypothesis that the probability of vesicular exocytosis at synapses is positively correlated with the pools of readily releasable synaptic vesicles, as shown for mammalian neurons grown in tissue culture. We compared synapses of two identified glutamatergic neurons: phasic (high-output, depressing) and tonic (low-output, facilitating) crustacean motor neurons, which differ 100- to 1000-fold in quantal content. Estimates of vesicles available for exocytosis were made from depletion during forced release and from electron microscopic observation of vesicles docked at synaptic membranes near active zones. Both measurements showed a significantly larger pool of readily releasable vesicles in facilitating synapses, despite their much lower quantal output during stimulation. Thus, the probability for release of docked vesicles is very much lower at facilitating synapses, and the presence of more docked vesicles does not predict higher synaptic release probability in these paired excitatory neurons.
Indexed as
Identifiers
12427821PMC6757826What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.