ArticleThe EMBO journal2002
A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- LMO2 regulates STAT3 localization to the nucleus in breast cancer cells.microPublication biology · 2026Article
- Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4+ and CD8+ T Cells, and Skin Mast Cells by Quantitative Transcriptomics.International journal of molecular sciences · 2024Article
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- Transcriptional Landscape of Enhancer RNAs in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus.Journal of inflammation research · 2022Article
- Article
- Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules.Developmental biology · 2018Article
- Article
- Altered DNA methylation profile in idiopathic pulmonary fibrosis.American journal of respiratory and critical care medicine · 2012Article
- Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway.Journal of neuroinflammation · 2011Article
- Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment.The Journal of biological chemistry · 2011Article
- Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.Annals of the New York Academy of Sciences · 2009Review
- Crif1 is a novel transcriptional coactivator of STAT3.The EMBO journal · 2008Article
- Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L).Molecular biology reports · 2006Article
- STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression.Oncogene · 2004Article
- Principles of interleukin (IL)-6-type cytokine signalling and its regulation.The Biochemical journal · 2003Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel cDNA EZI isolated as an oncostatin M- inducible gene encoded a protein containing 12 C2H2-type zinc fingers. EZI was found to transactivate the promoters that are also responsive to STAT3 and activated the acute phase response element (APRE) synergistically with STAT3. Co-immunoprecipitation demonstrated the association of EZI with STAT3, which was mediated by the N-terminal region (1-183) of EZI. The EZI mutant lacking this region showed reduced transcriptional activity, indicating that EZI and STAT3 function cooperatively through physical interaction. While EZI predominantly localized in the nucleus and enhanced the nuclear localization of STAT3, the EZI mutant lacking 11 zinc finger motifs failed to translocate into the nucleus and also inhibited nuclear localization of STAT3 as well as STAT3-mediated transactivation. These results indicate that EZI is a novel nuclear zinc finger protein that augments STAT3 activity by keeping it in the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.