ArticleJournal of bacteriology2002
Functional analysis of the heat shock regulator HrcA of Chlamydia trachomatis.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 56 citations in OpenAlex.
- A Refined Developmental Transcriptomic Landscape Reveals Four Coordinated Programs inbioRxiv : the preprint server for biology · 2026Article
- A lineage-specific heat-induced feedback loop controls HrcA to promote chlamydial fitness under stress.bioRxiv : the preprint server for biology · 2025Article
- A conservedMicrobiology (Reading, England) · 2025Article
- Expression activation of over 70% ofInfection and immunity · 2024Article
- Molecular pathogenesis ofFrontiers in cellular and infection microbiology · 2023Review
- Chlamydia trachomatis RsbU Phosphatase Activity Is Inhibited by the Enolase Product, Phosphoenolpyruvate.Journal of bacteriology · 2022Article
- Article
- GrgA overexpression inhibits Chlamydia trachomatis growth through sigmaMicrobial pathogenesis · 2021Article
- Robust Heat Shock Response inFrontiers in microbiology · 2021Article
- Article
- The Repressor Function of theJournal of bacteriology · 2020Article
- Identification of new DNA-associated proteins from Waddlia chondrophila.Scientific reports · 2019Article
- Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation inFrontiers in cellular and infection microbiology · 2017Review
- Regulation of Chlamydia Gene Expression by Tandem Promoters with Different Temporal Patterns.Journal of bacteriology · 2016Article
- Transcriptional regulation of the Chlamydia heat shock stress response in an intracellular infection.Molecular microbiology · 2015Article
- The transcriptional repressor EUO regulates both subsets of Chlamydia late genes.Molecular microbiology · 2014Article
- Chlamydia trachomatis protein GrgA activates transcription by contacting the nonconserved region of σ66.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Differential effects of DNA supercoiling on Chlamydia early promoters correlate with expression patterns in midcycle.Journal of bacteriology · 2012Article
- The early gene product EUO is a transcriptional repressor that selectively regulates promoters of Chlamydia late genes.Molecular microbiology · 2012Article
- A Chlamydia-specific C-terminal region of the stress response regulator HrcA modulates its repressor activity.Journal of bacteriology · 2011Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
HrcA is a regulator of bacterial heat shock gene expression that binds to a cis-acting DNA element called CIRCE. It has been proposed that HrcA and CIRCE function as a repressor-operator pair. We have purified recombinant HrcA from the pathogenic bacterium Chlamydia trachomatis and have shown that it is a DNA-binding protein that functions as a negative regulator of transcription. HrcA bound specifically to the CIRCE element in a concentration-dependent manner. HrcA repressed the in vitro transcription of a chlamydial heat shock promoter, and this repression was promoter specific. HrcA-mediated repression appears to be dependent on the topological state of the promoter, as repression on a supercoiled promoter template was greater than that on a linearized template. These results provide direct support for the role of HrcA as a transcriptional repressor in bacteria. This is the first report of the in vitro reconstitution of transcriptional regulation in Chlamydia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.