ArticleEnvironmental health perspectives2002
Induction of apoptosis in mammalian cells by cadmium and zinc.
Article in Environmental health perspectives, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Optimizing the osteogenic and angiogenic properties of nano-bioactive glass through adjustment of zinc and magnesium ion doping ratios: anFrontiers in bioengineering and biotechnology · 2026Article
- Article
- Zn-doped chitosan/alginate multilayer coatings on porous hydroxyapatite scaffold with osteogenic and antibacterial properties.International journal of bioprinting · 2023Article
- Lithium doped biphasic calcium phosphate: Structural analysis and osteo/odontogenic potentialFrontiers in bioengineering and biotechnology · 2022Article
- Fabrication of gelatin-based and ZnMaterials today. Bio · 2022Article
- Double-edged effects and mechanisms of ZnRSC advances · 2020Article
- Toxicity of TiONanomaterials (Basel, Switzerland) · 2019Article
- Zinc intoxication induces ferroptosis in A549 human lung cells.Metallomics : integrated biometal science · 2019Article
- Bi-functional titanium-polydopamine-zinc coatings for infection inhibition and enhanced osseointegration.RSC advances · 2019Article
- Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) activates Akt/protein kinase B independent of insulin signal transduction.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Article
- Cadmium Induces Apoptosis in Freshwater Crab Sinopotamon henanense through Activating Calcium Signal Transduction Pathway.PloS one · 2015Article
- Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition.Molecular human reproduction · 2014Article
- A novel reporter system for molecular imaging and high-throughput screening of anticancer drugs.Chembiochem : a European journal of chemical biology · 2013Article
- Article
- Characteristic, composition, and sources of TSP investigated by HRTEM/EDS and ESEM/EDS.Environmental monitoring and assessment · 2012Article
- Zinc maintains prophase I arrest in mouse oocytes through regulation of the MOS-MAPK pathway.Biology of reproduction · 2012Article
- Cadmium-induced apoptosis and necrosis in human osteoblasts: role of caspases and mitogen-activated protein kinases pathways.Journal of endocrinological investigation · 2012Article
- Mitochondrial electron transport chain in heavy metal-induced neurotoxicity: effects of cadmium, mercury, and copper.TheScientificWorldJournal · 2012Article
- Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Mechanism(s) of Toxic Action of Zn and Selenite: A Study on AS-30D Hepatoma Cells and Isolated Mitochondria.Biochemistry research international · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In various mammalian cells, two group IIb metals, cadmium and zinc, induce several morphological and biochemical effects that are salient features of programmed cell death. In C6 rat glioma cells, cadmium caused externalization of phosphatidylserine, breakdown of the mitochondrial membrane potential, activation of caspase-9, internucleosomal DNA fragmentation, chromatin condensation, and nuclear fragmentation. In NIH3T3 murine fibroblasts, cadmium-induced apoptosis was inhibited by overexpression of the antiapoptotic protein Bcl-2. Cadmium-induced DNA fragmentation in C6 cells was independent of inhibition of protein kinase A (PKA), protein kinase C (PKC), mitogen-activated protein kinase (MAPK), phosphatidylinositol-3-kinase, Ca-calmodulin-dependent protein kinase, and protein kinase G. Zinc at moderate concentrations (10-50 microM) protected against programmed cell death induced by cadmium, whereas deprivation of zinc by the membrane-permeable chelator N,N,N',N-terakis-(2-pyridylmethyl)ethylenediamine (TPEN) caused cell death with features characteristic of apoptosis. On the other hand, at elevated extracellular levels (150-200 microM), zinc alone caused programmed cell death in C6 cells. Zinc-induced apoptosis was independent of inhibition of PKA, PKC, guanylate cyclase and MAPK, but it was suppressed in the presence of 100 microM lanthanum chloride.
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