ArticlePharmaceutical research2002
A dispersion model for cellular signal transduction cascades.
Article in Pharmaceutical research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Diffusion dimensionality modeling of subcutaneous/intramuscular absorption of antibodies and long-acting injectables.Journal of pharmacokinetics and pharmacodynamics · 2025Article
- Methods of utilizing baseline values for indirect response models.Journal of pharmacokinetics and pharmacodynamics · 2009Article
- Investigation of a cellular pharmacodynamic model exhibiting sharp response sensitivity and tolerance.Journal of pharmacokinetics and pharmacodynamics · 2007Article
- A novel functional module detection algorithm for protein-protein interaction networks.Algorithms for molecular biology : AMB · 2006Article
- SPLINDID: a semi-parametric, model-based method for obtaining transcription rates and gene regulation parameters from genomic and proteomic expression profiles.Bioinformatics (Oxford, England) · 2005Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to evaluate the ability of the dispersion model to describe pharmacokinetic-pharmacodynamic data containing contributions from signal transduction cascades.
methodsThe partial differential equations and appropriate boundary conditions describing the dispersion model for signal transduction were obtained. Explicit analytical solutions to the dispersion equation were not available, and a numerical approach was necessary. Solutions were obtained by numerical inversion of the output Laplace transform. Generalized least square fitting was used to obtain parameter estimates for a variety of experimental data sets.
resultsThe parameters of the dispersion model estimate the relative roles of diffusion, convection, and chemical reaction in signal transduction. The model is capable of describing messenger RNA and protein expression kinetics induced by drug action.
conclusionsThe dispersion model may find potential applications in pharmacokinetic-pharmacodynamic models involving delayed drug effects mediated by transcriptional changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.