ArticleCurrent genetics2002
Proteolysis of a nucleotide excision repair protein by the 26 S proteasome.
Article in Current genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 79 citations in OpenAlex.
- Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer.PLoS genetics · 2022Article
- Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways.DNA repair · 2020Review
- Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Yeast importin-α (Srp1) performs distinct roles in the import of nuclear proteins and in targeting proteasomes to the nucleus.The Journal of biological chemistry · 2014Article
- A Synthetic Interaction between CDC20 and RAD4 in Saccharomyces cerevisiae upon UV Irradiation.Molecular biology international · 2014Article
- Article
- The ubiquitin-proteasome system of Saccharomyces cerevisiae.Genetics · 2012Review
- Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.The Journal of cell biology · 2012Article
- Yeast deubiquitinase Ubp3 interacts with the 26 S proteasome to facilitate Rad4 degradation.The Journal of biological chemistry · 2010Article
- Navigating the nucleotide excision repair threshold.Journal of cellular physiology · 2010Review
- Rad4 regulates protein turnover at a postubiquitylation step.Molecular biology of the cell · 2010Article
- The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation.Journal of cellular and molecular medicine · 2009Review
- Review
- Controlled degradation by ClpXP protease tunes the levels of the excision repair protein UvrA to the extent of DNA damage.Molecular microbiology · 2009Article
- Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast.Nucleic acids research · 2007Article
- Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones.Nucleic acids research · 2007Article
- Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair.Nucleic acids research · 2007Article
- Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair.The EMBO journal · 2006Article
- The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The 26 S proteasome degrades a broad spectrum of proteins and interacts with several nucleotide excision repair (NER) proteins, including the complex of Rad4 and Rad23 that binds preferentially to UV-damaged DNA. The rate of NER is increased in yeast strains with mutations in genes encoding subunits of the 26 S proteasome, indicating that it could negatively regulate a repair process. The specific function of the 26 S proteasome in DNA repair is unclear. It might degrade DNA repair proteins after repair is completed or act as a molecular chaperone to promote the assembly or disassembly of the repair complex. In this study, we show that Rad4 is ubiquitylated and that Rad23 can control this process. We also find that ubiquitylated Rad4 is degraded by the 26 S proteasome. However, the interaction of Rad23 with Rad4 is not only to control degradation of Rad4, but also to assist in assembling the NER incision complex at UV-induced cyclobutane pyrimidine dimers. We speculate that, following the completion of DNA repair, specific repair proteins might be degraded by the proteasome to regulate repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.