ArticleMolecular cell2002
Transcriptional inhibition of genes with severe histone h3 hypoacetylation in the coding region.
Article in Molecular cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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Who cites it
58 citing papers in PubMed, 119 citations in OpenAlex.
- NOGOB receptor deficiency increases cerebrovascular permeability and hemorrhage via impairing histone acetylation-mediated CCM1/2 expression.The Journal of clinical investigation · 2022Article
- The Role of Histone Acetylation-/Methylation-Mediated Apoptotic Gene Regulation in Hepatocellular Carcinoma.International journal of molecular sciences · 2020Review
- Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae.Epigenetics & chromatin · 2020Article
- Crosstalk between metabolism and epigenetic modifications in autoimmune diseases: a comprehensive overview.Cellular and molecular life sciences : CMLS · 2018Review
- Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation.The Journal of biological chemistry · 2018Article
- Recruitment of Fkh1 to replication origins requires precisely positioned Fkh1/2 binding sites and concurrent assembly of the pre-replicative complex.PLoS genetics · 2017Article
- Histone Posttranslational Modifications of CD4⁺ T Cell in Autoimmune Diseases.International journal of molecular sciences · 2016Review
- Anti-Inflammatory Effects of Spirulina platensis Extract via the Modulation of Histone Deacetylases.Nutrients · 2016Article
- Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.The Journal of experimental medicine · 2015Article
- Epigenetics in the Vascular Endothelium: Looking From a Different Perspective in the Epigenomics Era.Arteriosclerosis, thrombosis, and vascular biology · 2015Review
- Distribution and maintenance of histone H3 lysine 36 trimethylation in transcribed locus.PloS one · 2015Article
- Loss of Ubp3 increases silencing, decreases unequal recombination in rDNA, and shortens the replicative life span in Saccharomyces cerevisiae.Molecular biology of the cell · 2014Article
- Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex.FEBS open bio · 2014Article
- Distinct roles of the Gcn5 histone acetyltransferase revealed during transient stress-induced reprogramming of the genome.BMC genomics · 2013Article
- Chromatin-dependent and -independent regulation of DNA replication origin activation in budding yeast.EMBO reports · 2013Article
- DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.The Journal of biological chemistry · 2012Article
- Functional antagonism between Sas3 and Gcn5 acetyltransferases and ISWI chromatin remodelers.PLoS genetics · 2012Article
- Uniform distribution of elongating RNA polymerase II complexes in transcribed gene locus.The Journal of biological chemistry · 2011Article
- Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats.The Journal of physiology · 2011Article
- Mass spectrometric studies on epigenetic interaction networks in cell differentiation.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Changes in histone acetylation at promoters correlate with transcriptional activation and repression, but whether acetylation of histones in the coding region of genes is important for transcription is less clear. Here, we show that cells lacking the histone acetyltransferases Gcn5 and Elp3 have widespread and severe histone H3 hypoacetylation in chromatin. Surprisingly, severe hypoacetylation in the promoter does not invariably affect the ability of TBP to bind the TATA element, or transcription of the gene. By contrast, similar hypoacetylation of the coding region correlates with inhibition of transcription, and inhibition correlates better with the overall charge of the histone H3 tail than with hypoacetylation of specific lysine residues. These data provide insights into the effects of histone H3 hypoacetylation in vivo and underscore the importance of the overall charge of the histone tail for transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.