Evidence map›Paper›PMID 12419175›Full record

ReviewCurrent hypertension reports2002

Hypertension and lipids: lipid factors in the hypertension syndrome.

Gary E Sander, Thomas D Giles

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
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  11. Review
  12. Phthalate exposure and high blood pressure in adults: a cross-sectional study in China.Environmental science and pollution research international · 2018
    Article
  13. Association of hematocrit with blood pressure and hypertension.Journal of clinical laboratory analysis · 2017
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gary E SanderCardiovascular Research Laboratory, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA. gsande@lsuhsc.edu
Thomas D Giles
Louisiana State University Health Sciences Center New Orleans · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular risk factors are identified as physiologic, biochemical, and behavioral, and include hypertension, lipid abnormalities, and hyperglycemia. These factors constitute the "cardiovascular dysmetabolic syndrome" and damage the vascular endothelium by increasing concentrations of reactive molecular species, ultimately increasing cardiovascular morbidity and mortality. Multiple risk factors, particularly hypertension and hypercholesterolemia, often coexist in the same individual. Low-density lipoprotein cholesterol has been demonstrated to upregulate the AT(1) receptor, leading to increases in blood pressure. Treatment of hypercholesterolemia with medications, such as the hydroxymethylglutaryl coenzyme A reductase inhibitors or statins that decrease AT(1) receptor expression and activation, reduce not only cholesterol but blood pressure as well. Treatment of hypertension with angiotensin-converting enzyme inhibitors may also reduce cholesterol. Recognition and identification of multiple risk factors and appropriate treatment in a manner that minimizes excessive oxidative stress is critical to the maintenance of normal endothelial cell function and cardiovascular risk reduction.

Indexed as

Blood PressureHumansHypertensionLipidsRisk FactorsSyndromeUnited StatesLipids

Identifiers

PMID12419175
OpenAlexW2075093285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.