ArticleThe Biochemical journal2003
Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Review
- Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation.Cancer discovery · 2021Article
- Review
- Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.Biochimica et biophysica acta · 2015Review
- Multi-layered global gene regulation in mouse embryonic stem cells.Cellular and molecular life sciences : CMLS · 2015Review
- Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1.Acta crystallographica. Section F, Structural biology communications · 2014Article
- Nac1 interacts with the POZ-domain transcription factor, Miz1.Bioscience reports · 2014Article
- Article
- An overview of MYC and its interactome.Cold Spring Harbor perspectives in medicine · 2014Review
- Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation.PloS one · 2014Article
- DNA transposon-based gene vehicles - scenes from an evolutionary drive.Journal of biomedical science · 2013Review
- A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes.Nucleic acids research · 2013Article
- The Max b-HLH-LZ can transduce into cells and inhibit c-Myc transcriptional activities.PloS one · 2012Article
- Article
- Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells.Epigenetics & chromatin · 2011Article
- E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Regulation of the MAD1 promoter by G-CSF.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myc and Mad family proteins are central regulators of cellular proliferation and differentiation. We show that various Mad family genes have distinct patterns of expression during the chemically induced differentiation of mouse erythroleukaemia (MEL) cells, suggesting that they each serve a different function. Mad4 RNA is highly induced and persists in terminally differentiated cells, in agreement with observations in other systems. Using reporter gene assays in stably transfected MEL cells, we show that induction of Mad4 is mediated by a 49 nt core promoter region. We demonstrate that the initiator element is required for Mad4 activation, and show that induction is associated with the loss from the initiator of a complex that contains Miz-1 and c-Myc. Miz-1 activates the Mad4 promoter in transient transfection assays, and this effect is antagonized by c-Myc. We therefore identify Mad4 as a novel target of transcriptional repression by c-Myc. These data suggest that the expression of Mad4 in proliferating undifferentiated cells is suppressed by the binding of a c-Myc-Miz-1 repressor complex at the initiator, and that the activation of Mad4 during differentiation results, at least in part, from a decrease in c-Myc-mediated repression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.