ArticleProceedings of the National Academy of Sciences of the United States of America2002
Cytoskeletal-assisted dynamics of the mitochondrial reticulum in living cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- From Cell Architecture to Mitochondrial Signaling: Role of Intermediate Filaments in Health, Aging, and Disease.International journal of molecular sciences · 2025Review
- How cytoskeletal proteins regulate mitochondrial energetics in cell physiology and diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Anomalous Dynamics in Macromolecular Liquids.Polymers · 2022Article
- The evolution of vimentin and desmin inFrontiers in physiology · 2022Article
- Review
- Relationship Between Mitochondrial Structure and Bioenergetics inFrontiers in cell and developmental biology · 2020Article
- The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury.Antioxidants (Basel, Switzerland) · 2019Review
- Impact of dimensionality and network disruption on microrheology of cancer cells in 3D environments.PLoS computational biology · 2014Article
- Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.Circulation research · 2012Article
- Article
- Mitochondria are related to synaptic pathology in Alzheimer's disease.International journal of Alzheimer's disease · 2011Article
- RhoA and DIAPH1 mediate adrenocorticotropin-stimulated cortisol biosynthesis by regulating mitochondrial trafficking.Endocrinology · 2010Article
- Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity.American journal of physiology. Cell physiology · 2010Article
- Analysis of differentially expressed mitochondrial proteins in chromophobe renal cell carcinomas and renal oncocytomas by 2-D gel electrophoresis.International journal of biological sciences · 2010Article
- Actin polymerization driven mitochondrial transport in mating S. cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Subcellular dynamics and protein conformation fluctuations measured by Fourier imaging correlation spectroscopy.Annual review of physical chemistry · 2010Review
- Anisotropic rheology and directional mechanotransduction in vascular endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles.Medical & biological engineering & computing · 2008Article
- Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II.The Journal of cell biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subcellular organelle dynamics are strongly influenced by interactions with cytoskeletal filaments and their associated motor proteins, and lead to complex multiexponential relaxations that occur over a wide range of spatial and temporal scales. Here we report spatio-temporal measurements of the fluctuations of the mitochondrial reticulum in osteosarcoma cells by using Fourier imaging correlation spectroscopy, over time and distance scales of 10(-2) to 10(3) s and 0.5-2.5 microm. We show that the method allows a more complete description of mitochondrial dynamics, through the time- and length-scale-dependent collective diffusion coefficient D(k,tau), than available by other means. Addition of either nocodazole to disrupt microtubules or cytochalasin D to disassemble microfilaments simplifies the intermediate scattering function. When both drugs are used, the reticulum morphology of mitochondria is retained even though the cytoskeletal elements have been de-polymerized. The dynamics of the organelle are then primarily diffusive and can be modeled as a collection of friction points interconnected by elastic springs. This study quantitatively characterizes organelle dynamics in terms of collective cytoskeletal interactions in living cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.