ArticleMolecular and cellular biology2002
Normal p53 function in primary cells deficient for Siah genes.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- The diel disconnect between cell growth and division inFrontiers in microbiology · 2024Article
- Review
- DAZAP2 acts as specifier of the p53 response to DNA damage.Nucleic acids research · 2021Article
- The Ubiquitin Ligase SIAH2 Negatively Regulates Glucocorticoid Receptor Activity and Abundance.Biomedicines · 2020Article
- Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.Nature communications · 2017Article
- Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells.Oncogenesis · 2017Article
- Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.Cell cycle (Georgetown, Tex.) · 2015Article
- Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.EMBO molecular medicine · 2013Article
- SIAH proteins: critical roles in leukemogenesis.Leukemia · 2013Review
- USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains.The Journal of biological chemistry · 2011Article
- Article
- Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.Nature cell biology · 2010Article
- Viral infection of the placenta leads to fetal inflammation and sensitization to bacterial products predisposing to preterm labor.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases.The Journal of biological chemistry · 2009Article
- Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Generation and analysis of Siah2 mutant mice.Molecular and cellular biology · 2003Article
- Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation.The Journal of cell biology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression studies have suggested that Siah1 proteins may act as effectors of p53-mediated cellular responses and as regulators of mitotic progression. We have tested these hypotheses using Siah gene knockout mice. Siah1a and Siah1b were not induced by activation of endogenous p53 in tissues, primary murine embryonic fibroblasts (MEFs) or thymocytes. Furthermore, primary MEFs lacking Siah1a, Siah1b, Siah2, or both Siah2 and Siah1a displayed normal cell cycle progression, proliferation, p53-mediated senescence, and G(1) phase cell cycle arrest. Primary thymocytes deficient for Siah1a, Siah2, or both Siah2 and Siah1a, E1A-transformed MEFs lacking Siah1a, Siah1b, or Siah2, and Siah1b-null ES cells all underwent normal p53-mediated apoptosis. Finally, inhibition of Siah1b expression in Siah2 Siah1a double-mutant cells failed to inhibit cell division, p53-mediated induction of p21 expression, or cell cycle arrest. Our loss-of-function experiments do not support a general role for Siah genes in p53-mediated responses or mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.