ArticleThe Plant cell2002
Inducible DNA demethylation mediated by the maize Suppressor-mutator transposon-encoded TnpA protein.
Article in The Plant cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- An epiallele of a gene encoding a PfkB-type carbohydrate kinase affects plant architecture in maize.The Plant cell · 2024Article
- Arms race between anti-silencing and RdDM in noncoding regions of transposable elements.EMBO reports · 2023Article
- Transposable Elements: Distribution, Polymorphism, and Climate Adaptation inFrontiers in plant science · 2022Article
- Silencing ofGenetics · 2020Article
- A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation.Cell research · 2017Article
- Epigenome confrontation triggers immediate reprogramming of DNA methylation and transposon silencing in Arabidopsis thaliana F1 epihybrids.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Control of transposable elements in Arabidopsis thaliana.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Review
- Mobilization of a plant transposon by expression of the transposon-encoded anti-silencing factor.The EMBO journal · 2013Article
- Epigenetics: judge, jury and executioner of stem cell fate.Epigenetics · 2012Review
- Co-evolution between transposable elements and their hosts: a major factor in genome size evolution?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Review
- Tissue culture-induced transpositional activity of mPing is correlated with cytosine methylation in rice.BMC plant biology · 2009Article
- Interplay between SCARECROW, GA and LIKE HETEROCHROMATIN PROTEIN 1 in ground tissue patterning in the Arabidopsis root.The Plant journal : for cell and molecular biology · 2009Article
- Discrete and essential roles of the multiple domains of Arabidopsis FHY3 in mediating phytochrome A signal transduction.Plant physiology · 2008Article
- Transposable elements and the evolution of regulatory networks.Nature reviews. Genetics · 2008Review
- SmTRC1, a novel Schistosoma mansoni DNA transposon, discloses new families of animal and fungi transposons belonging to the CACTA superfamily.BMC evolutionary biology · 2006Article
- The temperature-dependent change in methylation of the Antirrhinum transposon Tam3 is controlled by the activity of its transposase.The Plant cell · 2006Article
- Epigenetics and its implications for plant biology. 1. The epigenetic network in plants.Annals of botany · 2005Review
- DNA hypomethylation in 5-azacytidine-induced early-flowering lines of flax.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2005Article
- Activation of a rice endogenous retrotransposon Tos17 in tissue culture is accompanied by cytosine demethylation and causes heritable alteration in methylation pattern of flanking genomic regions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heritable epigenetic inactivation of the maize Suppressor-mutator (Spm) transposon is associated with promoter methylation, and its reversal is mediated by the transposon-encoded TnpA protein. We have developed an assay that permits demethylation of the Spm sequence to be controlled by inducing the expression of TnpA in plant cells. Using this assay, we show that demethylation is a rapid, active process. TnpA is a weak transcriptional activator, and deletions that abolish its transcriptional activity also eliminate its demethylation activity. We show that cell cycle and DNA synthesis inhibitors interfere with TnpA-mediated Spm demethylation. We further show that TnpA has a much lower affinity for fully methylated than for hemimethylated or unmethylated DNA fragments derived from Spm termini. Based on these observations, we suggest that TnpA binds to the postreplicative, hemimethylated Spm sequence and promotes demethylation either by creating an appropriate demethylation substrate or by itself participating in or recruiting a demethylase.
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