ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Nitric oxide is necessary for multiple memory processes after learning that a food is inedible in aplysia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 95 citations in OpenAlex.
- Characterization of nitric oxide in Octopus maya nervous system and its potential role in sensory perception.Biology open · 2024Article
- Multiple changes in connectivity between buccal ganglia mechanoafferents and motor neurons with different functions after learning that food is inedible inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- An in vitro analog of learning that food is inedible inLearning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Role of NADCellular and molecular neurobiology · 2023Review
- Improvements in operant memory ofFrontiers in behavioral neuroscience · 2023Article
- Neurotransmission and neuromodulation systems in the learning and memory network of Octopus vulgaris.Journal of morphology · 2022Article
- Article
- Multiple Local Synaptic Modifications at Specific Sensorimotor Connections after Learning Are Associated with Behavioral Adaptations That Are Components of a Global Response Change.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Successful and unsuccessful attempts to swallow in a reducedLearning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia.Behavioural brain research · 2019Article
- NO is required for memory formation and expression of memory, and for minor behavioral changes during training with inedible food inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Molecular correlates of separate components of training that contribute to long-term memory formation after learning that food is inedible inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Nitric oxide contributes to high-salt perception in a blood-sucking insect model.Scientific reports · 2017Article
- Sleep supports inhibitory operant conditioning memory inLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Role of proteasome-dependent protein degradation in long-term operant memory in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Effect of Hypoxic Injury in Mood Disorder.Neural plasticity · 2017Review
- Article
- Associative learning in invertebrates.Cold Spring Harbor perspectives in biology · 2015Review
- Nitric Oxide-Mediated Modulation of Central Network Dynamics during Olfactory Perception.PloS one · 2015Article
- Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) signaling was inhibited via N(omega)-nitro-L-arginine methyl ester (L-NAME) during and after training Aplysia that a food is inedible. Treating animals with L-NAME 10 min before the start of training blocked the formation of three separable memory processes: (1) short-term, (2) intermediate-term, and (3) long-term memory. The treatment also attenuated, but did not block, a fourth memory process, very short-term memory. L-NAME had little or no effect on feeding behavior per se or on most aspects of the animals' behavior while they were being trained, indicating that the substance did not cause a pervasive modulation or poisoning of many aspects of feeding and other behaviors. Application of L-NAME within 1 min after the training had no effect on short- or long-term memory, indicating that NO signaling was not needed during memory consolidation. Treating animals with the NO scavenger 2-phenyl-4,4,5,5-tetramethyl-imidazdine-1-oxy-3-oxide before training also blocked long-term memory. Memory was not blocked by D-NAME, or by the simultaneous treatment with L-NAME and the NO donor S-nitroso-N-acetyl-penicillamine, confirming that the effect of L-NAME is attributable to its effect as a competitive inhibitor of L-arginine for NO synthase in the production of NO rather than to possible effects at other sites. These data indicate that NO signaling during training plays a critical role in the formation of multiple memory processes.
Indexed as
Identifiers
12417683PMC6758034W2115089079What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.