ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 90 citations in OpenAlex.
- Knockdown of PR-DUB subunit calypso in the developing Drosophila eye and wing results in mis-patterned tissues with altered size and shape.G3 (Bethesda, Md.) · 2025Article
- A Brief Overview of Ethanol Tolerance and Its Potential Association with Circadian Rhythm inInternational journal of molecular sciences · 2024Review
- Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models.International journal of molecular sciences · 2024Review
- Review
- Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development.PloS one · 2024Article
- Lysines K117 and K147 play conserved roles in Ras activation from Drosophila to mammals.G3 (Bethesda, Md.) · 2023Article
- Methods for Exploring the Circuit Basis of Ethanol-Induced Changes inCold Spring Harbor protocols · 2023Article
- Translational relevance of forward genetic screens in animal models for the study of psychiatric disease.Neuroscience and biobehavioral reviews · 2022Review
- TheGenome research · 2021Article
- Flying Together:International journal of molecular sciences · 2020Review
- Normal Ethanol Sensitivity and Rapid Tolerance Require the G Protein Receptor Kinase 2 in Ellipsoid Body Neurons in Drosophila.Alcoholism, clinical and experimental research · 2020Article
- A Serotonin-Modulated Circuit Controls Sleep Architecture to Regulate Cognitive Function Independent of Total Sleep in Drosophila.Current biology : CB · 2019Article
- Amnesiac Is Required in the Adult Mushroom Body for Memory Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Perineurial Barrier Glia Physically Respond to Alcohol in an Akap200-Dependent Manner to Promote Tolerance.Cell reports · 2018Article
- Ethanol stimulates the in vivo axonal movement of neuropeptide dense-core vesicles in Drosophila motor neurons.Journal of neurochemistry · 2018Article
- Article
- Genetics and genomics of alcohol responses in Drosophila.Neuropharmacology · 2017Review
- Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience.Annual review of genetics · 2016Review
- I Believe I Can Fly!: Use of Drosophila as a Model Organism in Neuropsychopharmacology Research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila.Journal of biological rhythms · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Ethanol has complex but similar effects on behavior in mammals and the fruit fly Drosophila melanogaster. In addition, genetic and pharmacological approaches have implicated the cAMP pathway in the regulation of ethanol-induced behaviors in both flies and rodents. Here we examine the neuroanatomical loci that modulate ethanol sensitivity in Drosophila by targeting the expression of an inhibitor of cAMP-dependent protein kinase (PKA) to specific regions in the fly's brain. Expression of the inhibitor in most brain regions or in muscle has no effect on behavior. In contrast, inhibition of PKA in a relatively small number of cells, possibly neurosecretory cells, in the fly's brain is sufficient to decrease sensitivity to the incoordinating effects of ethanol. Additional brain areas are, however, also involved. The mushroom bodies, brain structures where cAMP signaling is required for olfactory classical conditioning, are dispensable for the regulation of ethanol sensitivity. Finally, different behavioral effects of ethanol, motor incoordination and sedation, appear to be regulated by PKA function in distinct brain regions. We conclude that the regulation of ethanol-induced behaviors by PKA involves complex interactions among groups of cells that mediate either increased or reduced sensitivity to the acute intoxicating effects of ethanol.
Indexed as
Identifiers
12417673PMC6758036W1931217601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.