ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Dopamine activates noradrenergic receptors in the preoptic area.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The trial behind it
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Who cites it
47 citing papers in PubMed, 105 citations in OpenAlex.
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- Dopaminergic modulation of propofol-induced activation in VLPO neurons: the role of D1 receptors in sleep-promoting neural circuits.Frontiers in neuroscience · 2024Article
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
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- Using seasonality and birdsong to understand mechanisms underlying context-appropriate shifts in social motivation and reward.Hormones and behavior · 2022Review
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- Landscape of GPCR expression along the mouse nephron.American journal of physiology. Renal physiology · 2021Article
- The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides.Nature communications · 2020Article
- Effects of Prenatal Exposure to a Low-Dose of Bisphenol A on Sex Differences in Emotional Behavior and Central AlphaInternational journal of molecular sciences · 2020Article
- αFrontiers in pharmacology · 2020Review
- Dopamine: Functions, Signaling, and Association with Neurological Diseases.Cellular and molecular neurobiology · 2019Review
- Reversal of dopamine-mediated firing inhibition through activation of the dopamine transporter in substantia nigra pars compacta neurons.British journal of pharmacology · 2018Article
- Multiplexed profiling of GPCR activities by combining split TEV assays and EXT-based barcoded readouts.Scientific reports · 2018Article
- Activation of the GABAergic Parafacial Zone Maintains Sleep and Counteracts the Wake-Promoting Action of the Psychostimulants Armodafinil and Caffeine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
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- Contributions of testosterone and territory ownership to sexually-motivated behaviors and mRNA expression in the medial preoptic area of male European starlings.Hormones and behavior · 2016Article
- Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers.Frontiers in pharmacology · 2015Article
- Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Sociosexual investigation in sexually experienced, hormonally manipulated male leopard geckos: relation with phosphorylated DARPP-32 in dopaminergic pathways.Journal of experimental zoology. Part A, Ecological genetics and physiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Dopamine (DA) facilitates male sexual behavior and modulates aromatase activity in the quail preoptic area (POA). Aromatase neurons in the POA receive dopaminergic inputs, but the anatomical substrate that mediates the behavioral and endocrine effects of DA is poorly understood. Intracellular recordings showed that 100 microm DA hyperpolarizes most neurons in the medial preoptic nucleus (80%) by a direct effect, but depolarizes a few others (10%). DA-induced hyperpolarizations were not blocked by D1 or D2 antagonists (SCH-23390 and sulpiride). Extracellular recordings confirmed that DA inhibits the firing of most cells (52%) but excites a few others (24%). These effects also were not affected by DA antagonists (SCH-23390 and sulpiride) but were blocked by alpha2-(yohimbine) and alpha1-(prazosin) noradrenergic receptor antagonists, respectively. Two dopamine-beta-hydroxylase (DBH) inhibitors (cysteine and fusaric acid) did not block the DA-induced effects, indicating that DA is not converted into norepinephrine (NE) to produce its effects. The pK(B) of yohimbine for the receptor involved in the DA- and NE-induced inhibitions was similar, indicating that the two monoamines interact with the same receptor. Together, these results demonstrate that the effects of DA in the POA are mediated mostly by the activation of alpha2 (inhibition) and alpha1 (excitation) adrenoreceptors. This may explain why DA affects the expression of male sexual behavior through its action in the POA, which contains high densities of alpha2-noradrenergic but limited amounts of DA receptors. This study thus clearly demonstrates the existence of a cross talk within CNS catecholaminergic systems between a neurotransmitter and heterologous receptors.
Indexed as
Identifiers
12417657PMC3538175W2117818413What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.