ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
The extraretinal eyelet of Drosophila: development, ultrastructure, and putative circadian function.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed, 234 citations in OpenAlex.
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- A one-day journey to the suburbs: circadian clock in the Drosophila visual system.The FEBS journal · 2025Review
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- Circadian entrainment to red-light Zeitgebers and action spectrum for entrainment in the jewel wasp Nasonia vitripennis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Light and dopamine impact two circadian neurons to promote morning wakefulness.bioRxiv : the preprint server for biology · 2024Article
- Gravisensation and modulation of gravitactic responses by other sensory cues in the monarch butterfly (Danaus plexippus).The Journal of experimental biology · 2023Article
- Circadian rhythm entrainment of the jewel wasp,Proceedings. Biological sciences · 2023Article
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- miR-277 regulates the phase of circadian activity-rest rhythm inFrontiers in physiology · 2023Article
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- Development of the ocellar visual system in Drosophila melanogaster.The FEBS journal · 2022Article
- Insect opsins and evo-devo: what have we learned in 25 years?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Connectomic analysis of theeLife · 2022Article
- Light exposure during development affects physiology of adults inFrontiers in physiology · 2022Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Circadian rhythms can be entrained by light to follow the daily solar cycle. In Drosophila melanogaster a pair of extraretinal eyelets expressing immunoreactivity to Rhodopsin 6 each contains four photoreceptors located beneath the posterior margin of the compound eye. Their axons project to the region of the pacemaker center in the brain with a trajectory resembling that of Bolwig's organ, the visual organ of the larva. A lacZ reporter line driven by an upstream fragment of the developmental gap gene Krüppel is a specific enhancer element for Bolwig's organ. Expression of immunoreactivity to the product of lacZ in Bolwig's organ persists through pupal metamorphosis and survives in the adult eyelet. We thus demonstrate that eyelet derives from the 12 photoreceptors of Bolwig's organ, which entrain circadian rhythmicity in the larva. Double labeling with anti-pigment-dispersing hormone shows that the terminals of Bolwig's nerve differentiate during metamorphosis in close temporal and spatial relationship to the ventral lateral neurons (LN(v)), which are essential to express circadian rhythmicity in the adult. Bolwig's organ also expresses immunoreactivity to Rhodopsin 6, which thus continues in eyelet. We compared action spectra of entrainment in different fly strains: in flies lacking compound eyes but retaining eyelet (so(1)), lacking both compound eyes and eyelet (so(1);gl(60j)), and retaining eyelet but lacking compound eyes as well as cryptochrome (so(1);cry(b)). Responses to phase shifts suggest that, in the absence of compound eyes, eyelet together with cryptochrome mainly mediates phase delays. Thus a functional role in circadian entrainment first found in Bolwig's organ in the larva is retained in eyelet, the adult remnant of Bolwig's organ, even in the face of metamorphic restructuring.
Indexed as
Identifiers
12417651PMC6758046W1659345007What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.