ArticleThe Journal of experimental medicine2002
Quantitative and qualitative changes in V-J alpha rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor alpha chain repertoire.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 92 citations in OpenAlex.
- Clonal restriction and predominance of regulatory T cells in coronary thrombi of patients with acute coronary syndromes.European heart journal · 2015Trial
- Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Trial
- Preselection CD4bioRxiv : the preprint server for biology · 2025Article
- Inactivation of GSK3β by SerCell death and differentiation · 2025Article
- Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus.eLife · 2024Article
- A mathematical model simulating the adaptive immune response in various vaccines and vaccination strategies.Scientific reports · 2024Article
- The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants.Science (New York, N.Y.) · 2024Article
- Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A Novel Mathematical Model That Predicts the Protection Time of SARS-CoV-2 Antibodies.Viruses · 2023Article
- P140 Peptide Leads to Clearance of Autoreactive Lymphocytes and Normalizes Immune Response in Lupus-Prone Mice.Frontiers in immunology · 2022Article
- Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids.Frontiers in immunology · 2021Article
- Emergence of a "Cyclosome" in a Primitive Network Capable of Building "Infinite" Proteins.Life (Basel, Switzerland) · 2019Article
- Genesis of the αβ T-cell receptor.PLoS computational biology · 2019Article
- Sequencing the peripheral blood B and T cell repertoire - Quantifying robustness and limitations.Journal of immunological methods · 2018Article
- Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.Cell reports · 2017Article
- A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) α and β repertoires and identifying potential new invariant TCR α chains.BMC immunology · 2016Article
- A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires.Nature immunology · 2015Article
- The immune system as a self-centered network of lymphocytes.Immunology letters · 2015Review
- Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains.Protein & cell · 2014Article
- The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis.Frontiers in immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge of the complete nucleotide sequence of the mouse TCRAD locus allows an accurate determination V-J rearrangement status. Using multiplex genomic PCR assays and real time PCR analysis, we report a comprehensive and systematic analysis of the V-J recombination of TCR alpha chain in normal mouse thymocytes during development. These respective qualitative and quantitative approaches give rise to four major points describing the control of gene rearrangements. (a) The V-J recombination pattern is not random during ontogeny and generates a limited TCR alpha repertoire; (b) V-J rearrangement control is intrinsic to the thymus; (c) each V gene rearranges to a set of contiguous J segments with a gaussian-like frequency; (d) there are more rearrangements involving V genes at the 3' side than 5' end of V region. Taken together, this reflects a preferential association of V and J gene segments according to their respective positions in the locus, indicating that accessibility of both V and J regions is coordinately regulated, but in different ways. These results provide a new insight into TCR alpha repertoire size and suggest a scenario for V usage during differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.