ArticleThe Journal of cell biology2002
Accumulation of endoplasmic membranes and novel membrane-bound ribosome-signal recognition particle receptor complexes in Escherichia coli.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Membrane Protein Insertion in Cells: Principles, Pathways, and Quality Control.Chemical reviews · 2026Review
- Transcending membrane barriers: advances in membrane engineering to enhance the production capacity of microbial cell factories.Microbial cell factories · 2024Review
- Little reason to call them small noncoding RNAs.Frontiers in microbiology · 2023Article
- Manipulating the position of DNA expression cassettes using location tags fused to dCas9 (Cas9-Lag) to improve metabolic pathway efficiency.Microbial cell factories · 2020Article
- Ectopic Neo-Formed Intracellular Membranes inBiomolecules · 2018Review
- Engineering membrane morphology and manipulating synthesis for increased lycopene accumulation in3 Biotech · 2018Article
- The bacterial Sec system is required for the organization and function of the MreB cytoskeleton.PLoS genetics · 2017Article
- Sponge-associated bacteria mineralize arsenic and barium on intracellular vesicles.Nature communications · 2017Article
- Evidence for a cytoplasmic pool of ribosome-free mRNAs encoding inner membrane proteins in Escherichia coli.PloS one · 2017Article
- Proteomic profiling of the outer membrane fraction of the obligate intracellular bacterial pathogen Ehrlichia ruminantium.PloS one · 2015Article
- Consequences of depletion of the signal recognition particle in Escherichia coli.The Journal of biological chemistry · 2011Article
- Genetic evidence for functional interaction of the Escherichia coli signal recognition particle receptor with acidic lipids in vivo.The Journal of biological chemistry · 2010Article
- Uniting sex and eukaryote origins in an emerging oxygenic world.Biology direct · 2010Article
- Article
- Evolution: like any other science it is predictable.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
- Massive formation of intracellular membrane vesicles in Escherichia coli by a monotopic membrane-bound lipid glycosyltransferase.The Journal of biological chemistry · 2009Article
- Depletion of the signal recognition particle receptor inactivates ribosomes in Escherichia coli.Journal of bacteriology · 2009Article
- Biogenesis of bacterial membrane vesicles.Molecular microbiology · 2009Article
- Studying membrane proteins through the eyes of the genetic code revealed a strong uracil bias in their coding mRNAs.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Effects of SecE depletion on the inner and outer membrane proteomes of Escherichia coli.Journal of bacteriology · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Escherichia coli, ribosomes must interact with translocons on the membrane for the proper integration of newly synthesized membrane proteins, cotranslationally. Previous in vivo studies indicated that unlike the E. coli signal recognition particle (SRP), the SRP receptor FtsY is required for membrane targeting of ribosomes. Accordingly, a putative SRP-independent, FtsY-mediated ribosomal targeting pathway has been suggested (Herskovits, A.A., E.S. Bochkareva, and E. Bibi. 2000. Mol. Microbiol. 38:927-939). However, the nature of the early contact of ribosomes with the membrane, and the involvement of FtsY in this interaction are unknown. Here we show that in cells depleted of the SRP protein, Ffh or the translocon component SecE, the ribosomal targeting pathway is blocked downstream and unprecedented, membrane-bound FtsY-ribosomal complexes are captured. Concurrently, under these conditions, novel, ribosome-loaded intracellular membrane structures are formed. We propose that in the absence of a functional SRP or translocon, ribosomes remain jammed at their primary membrane docking site, whereas FtsY-dependent ribosomal targeting to the membrane continues. The accumulation of FtsY-ribosome complexes induces the formation of intracellular membranes needed for their quantitative accommodation. Our results with E. coli, in conjunction with recent observations made with the yeast Saccharomyces cerevisiae, raise the possibility that the SRP receptor-mediated formation of intracellular membrane networks is governed by evolutionarily conserved principles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.