ArticleThe Journal of clinical investigation2002
Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway.
Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 64 citations in OpenAlex.
- Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development.F1000Research · 2024Review
- Role of the Lymphotoxin/LIGHT System in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues.Frontiers in immunology · 2014Review
- Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation.Immunity · 2013Article
- Lymphotoxin α1β2 expression on B cells is required for follicular dendritic cell activation during the germinal center response.European journal of immunology · 2013Article
- Secretory IgA: Designed for Anti-Microbial Defense.Frontiers in immunology · 2013Article
- Article
- Regulation of humoral immunity by complement.Immunity · 2012Review
- Lymphotoxin-sensitive microenvironments in homeostasis and inflammation.Frontiers in immunology · 2012Article
- Human immune system mice: current potential and limitations for translational research on human antibody responses.Immunologic research · 2011Article
- A lymphotoxin-driven pathway to hepatocellular carcinoma.Cancer cell · 2009Article
- B cell acquisition of antigen in vivo.Current opinion in immunology · 2009Review
- ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation.Blood · 2007Article
- Molecular pathways in follicular lymphoma.Leukemia · 2007Review
- A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys.The American journal of pathology · 2006Article
- The lymphotoxin pathway: beyond lymph node development.Immunologic research · 2006Review
- Role of lymphotoxin in experimental models of infectious diseases: potential benefits and risks of a therapeutic inhibition of the lymphotoxin-beta receptor pathway.Infection and immunity · 2005Review
- A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT.The Journal of clinical investigation · 2003Article
- Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility.Journal of virology · 2003Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reticular networks in lymphoid organs play critical roles in the organization of local microenvironments. A number of these elements are maintained by continual signaling through the lymphotoxin system. Evaluation of the lymphotoxin (LT) pathway in primates using a fusion protein decoy provides a unique opportunity to assess modulation of splenic microenvironments in a species with considerably greater background immunological activity compared with rodents. Within the germinal center microenvironment, treatment resulted in a collapse of follicular dendritic cell (FDC) networks and in the disappearance of a ringlike network of immune complex-carrying cells, although some other attributes of the germinal center appeared to be unaltered. Treatment also resulted in changes in the splenic marginal zone, a microenvironment where the architecture is notably different from that of the rodent. Cessation of treatment and recovery allowed us to monitor reemergence of these cell types and revealed that FDCs rely on LT-dependent signals to recompact into appropriately positioned tight networks. Despite the loss of FDC networks, the primary Ab response to keyhole limpet hemocyanin was unaltered over a 20-day period. Manipulation of these microenvironments may represent a novel approach to modulating immune function in human disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.