ArticleEnvironmental health perspectives2002
Cytogenetic monitoring in a population occupationally exposed to pesticides in Ecuador.
Article in Environmental health perspectives, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Non-cancer health effects of pesticides: systematic review and implications for family doctors.Canadian family physician Medecin de famille canadien · 2007Pooled it
- Assessment of the anti-inflammatory and analgesic effects ofThe Libyan journal of medicine · 2023Article
- Profile of Chromosomal Alterations, Chromosomal Instability and Clonal Heterogeneity in Colombian Farmers Exposed to Pesticides.Frontiers in genetics · 2022Article
- Assessment of Cytogenetic Damage and Cholinesterases' Activity in Workers Occupationally Exposed to Pesticides in Zamora-Jacona, Michoacan, Mexico.International journal of environmental research and public health · 2021Article
- Antigenotoxic and Antimutagenic Effects ofPreventive nutrition and food science · 2020Article
- In vitro cytogenetic toxicity of bezafibrate in human peripheral blood lymphocytes.Cytotechnology · 2017Article
- Genotoxicity and cytotoxicity of copper oxychloride in cultured human lymphocytes using cytogenetic and molecular tests.Cytotechnology · 2016Article
- In vitro genotoxicity assessment of the synthetic plant growth regulator, 1-naphthaleneacetamide.Cytotechnology · 2016Article
- Genetics and genomic medicine in Ecuador.Molecular genetics & genomic medicine · 2016Article
- Salivary acetylcholinesterase activity is increased in Parkinson's disease: a potential marker of parasympathetic dysfunction.Parkinson's disease · 2015Article
- In vitro genotoxicity and cytotoxicity of a particular combination of pemetrexed and cefixime in human peripheral blood lymphocytes.SpringerPlus · 2015Article
- Genotoxicity of pemetrexed in human peripheral blood lymphocytes.Cytotechnology · 2013Article
- Lower acetylcholinesterase activity among children living with flower plantation workers.Environmental research · 2012Article
- Genotoxicity studies performed in the ecuadorian population.Molecular biology international · 2012Article
- The genotoxic and anti-genotoxic effects of Stachys petrokosmos leaf extract in human lymphocytes using microsomal fractions.Cytotechnology · 2012Article
- The effects of 4-thujanol on chromosome aberrations, sister chromatid exchanges and micronucleus in human peripheral blood lymphocytes.Cytotechnology · 2011Article
- In vitro genotoxicity of rocuronium bromide in human peripheral lymphocytes.Cytotechnology · 2011Article
- The effects of boric acid on sister chromatid exchanges and chromosome aberrations in cultured human lymphocytes.Cytotechnology · 2008Article
- Meeting report: threats to human health and environmental sustainability in the pacific basin.Environmental health perspectives · 2007Article
- Genetic Alterations in Pesticide Exposed Bolivian Farmers: An evaluation by analysis of chromosomal aberrations and the comet assay.Biomarker insights · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed the incidence of structural and numerical chromosomal aberrations (CAs) in workers of a plantation of flowers located in Quito, Ecuador, in South America. This study included 41 individuals occupationally exposed to 27 pesticides, some of which are restricted in many countries and are classified as extremely toxic by the World Health Organization; among these are aldicarb and fenamiphos. The same number of individuals of the same age, sex, and geographic area were selected as controls. Workers exposed to these pesticides showed an increased frequency of CA compared with control group (20.59% vs. 2.73%; p < 0.001). We conclude that screening for CA is an adequate biomarker for evaluating and detecting genotoxicity resulting from exposure to pesticides. Levels of erythrocyte acetylcholinesterase were also determined as a complementary metabolic study. Levels below the optimal (> 28 U/mL blood) were found in 88% of exposed individuals; this clearly shows the effect of organophosphate pesticides. When comparing the levels of acetylcholinesterase and structural CA frequencies, there was a negative linear correlation (r = 0.416; p < 0.01). We conclude that by using both analyses it may be possible to estimate damage produced by exposure to organophosphate pesticides.
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