ArticleJournal of muscle research and cell motility2002
Myosin heavy chain isoform expression and Ca2 +-stimulated ATPase activity in single fibres of toad rectus abdominis muscle.
Article in Journal of muscle research and cell motility, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 10 citations in OpenAlex.
- Does the unusual phenomenon of sustained force circumvent the speed-endurance trade-off in the jaw muscle of the southern alligator lizard (Elgaria multicarinata)?The Journal of experimental biology · 2025Article
- Myosin heavy chain isoform composition and stretch activation kinetics in single fibres of Xenopus laevis iliofibularis muscle.The Journal of physiology · 2006Article
- Tubular system excitability: an essential component of excitation-contraction coupling in fast-twitch fibres of vertebrate skeletal muscle.Journal of muscle research and cell motility · 2006Review
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Segments of single fibres from the rectus abdominis (RA) muscles of adult and juvenile cane toads (Bufo marinus) were examined for myosin heavy chain (mHC) isoform expression and Ca2+-stimulated MgATPase activity. mHC isoform analyses were carried out using the recently developed alanine-SDS-PAGE method, which separates one tonic (BmHCT) and three twitch (BmHC1, BmHC2, BmHC3) mHC isoforms in toad skeletal muscle. Ca2+-stimulated MgATPase activity was measured by spectrophotometric determination of Pi, under conditions in which the ATPase associated with the sarcoplasmic reticulum (SR ATPase) was suppressed by feedback inhibition. The mHC-based fibre types identified in this study include three pure twitch fibre types (t1, t2 and t3), expressing BmHC1, BmHC2 or BmHC3 respectively, and seven hybrid fibre types co-expressing a combination of two or three twitch and tonic or twitch and twitch mHC isoforms. The fibre populations dissected from juvenile and adult toad muscles contained 49.4% (juvenile) and 73.7% (adult) mHC hybrids. The average values for Ca2+-stimulated MgATPase in pure twitch fibres and in fibres expressing predominantly (> or = 95%) the tonic mHC isoform (Tp fibres) differed significantly (P < 0.05) from each other and decreased in the order t1 > t2 > t3 > Tp. We conclude that (i) in RA muscles of both juvenile and adult cane toads there is a large proportion of mHC hybrids, some of which co-express twitch and tonic mHC isoforms and (ii) ATPase activities associated with the four mHC isoforms expressed in toad skeletal muscles decrease in the order BmHC1 > BmHC2 > BmHC3 > BmHCT.
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