Evidence map›Paper›PMID 12414980›Full record

ArticleJournal of virology2002

Host range and receptor binding properties of vectors bearing feline leukemia virus subgroup B envelopes can be modulated by envelope sequences outside of the receptor binding domain.

Peggy Ho Faix, Steven A Feldman, Julie Overbaugh, Maribeth V Eiden

Abstract readComparative Study
In one paragraph

Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Peggy Ho FaixLaboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
Steven A Feldman
Julie Overbaugh
Maribeth V Eiden

Funding

Viral &Cellular Factors Governing Retroviral InfectionZ01MH002592 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI EIDEN, MARIBETH V. · 1991 to 2008
$2.6M
REGULATION OF FELV REPLICATION AND PATHOGENESISR01CA051080 · NCI · UNIVERSITY OF WASHINGTON · PI OVERBAUGH, JULIE M · 1990 to 2004
$1.5M
NCI NIH HHS CA51080NCI NIH HHS R01 CA051080
6 · The paper itself

Abstract

To evaluate host range differences between two different strains of feline leukemia virus subgroup B (FeLV-B), we compared the binding and infectivity patterns of retrovirus vectors bearing either FeLV-B-90Z or FeLV-B-GA envelopes. We report here that the ability of these envelopes to utilize different Pit1 orthologs is mediated primarily by the receptor binding domain; however, in the case of FeLV-B-90Z, the C terminus also contributes to the recognition of certain Pit1 orthologs.

Indexed as

AnimalsCatsCell LineGenetic VectorsLeukemia Virus, FelineMiceMinkProtein Structure, TertiaryRabbitsRatsReceptors, VirusRecombinant Fusion ProteinsRetroviridaeSpecies SpecificityViral Envelope ProteinsVirulenceleukemia virus receptor, gibbon apeReceptors, VirusRecombinant Fusion ProteinsViral Envelope Proteins

Identifiers

PMID12414980
PMCPMC136888

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.