ArticleJournal of virology2002
Processing and degradation of exogenous prion protein by CD11c(+) myeloid dendritic cells in vitro.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- CpG oligodeoxynucleotide reduces PrPMolecules and cells · 2026Article
- Experimental inoculation of CD11cAccess microbiology · 2020Article
- The Good, the Bad, and the Ugly of Dendritic Cells during Prion Disease.Journal of immunology research · 2015Review
- Efficient uptake and dissemination of scrapie prion protein by astrocytes and fibroblasts from adult hamster brain.PloS one · 2015Article
- Human tonsil-derived follicular dendritic-like cells are refractory to human prion infection in vitro and traffic disease-associated prion protein to lysosomes.The American journal of pathology · 2014Article
- A specific population of abnormal prion protein aggregates is preferentially taken up by cells and disaggregated in a strain-dependent manner.Journal of virology · 2013Article
- Prion disease and the innate immune system.Viruses · 2012Review
- Orally administered prion protein is incorporated by m cells and spreads into lymphoid tissues with macrophages in prion protein knockout mice.The American journal of pathology · 2011Article
- Initial fate of prions upon peripheral infection: half-life, distribution, clearance, and tissue uptake.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Spreading of prions from the immune to the peripheral nervous system: a potential implication of dendritic cells.Histochemistry and cell biology · 2010Article
- Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo.Neurobiology of disease · 2009Article
- Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice.Journal of virology · 2008Article
- Oral scrapie infection modifies the homeostasis of Peyer's patches' dendritic cells.Histochemistry and cell biology · 2007Article
- Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cells.Journal of virology · 2006Article
- Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure.Immunology · 2005Article
- High incidence of scrapie induced by repeated injections of subinfectious prion doses.Journal of virology · 2005Article
- Neuroinvasion by scrapie following inoculation via the skin is independent of migratory Langerhans cells.Journal of virology · 2005Article
- Scrapie protein degradation by cysteine proteases in CD11c+ dendritic cells and GT1-1 neuronal cells.Journal of virology · 2004Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system plays an important role in facilitating the spread of prion infections from the periphery to the central nervous system. CD11c(+) myeloid dendritic cells (DC) could, due to their subepithelial location and their migratory capacity, be early targets for prion infection and contribute to the spread of infection. In order to analyze mechanisms by which these cells may affect prion propagation, we studied in vitro the effect of exposing such DC to scrapie-infected GT1-1 cells, which produce the scrapie prion protein PrP(Sc). In this system, the DC efficiently engulfed the infected GT1-1 cells. Unexpectedly, PrP(Sc), which is generally resistant to protease digestion, was processed and rapidly degraded. Based on this observation we speculate that CD11c(+) DC may play a dual role in prion infections: on one hand they may facilitate neuroinvasion by transfer of the infectious agent as suggested from in vivo studies, but on the other hand they may protect against the infection by causing an efficient degradation of PrP(Sc). Thus, the migrating and highly proteolytic CD11c(+) myeloid DC may affect the balance between propagation and clearance of PrP(Sc) in the organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.