ArticleJournal of virology2002
Hepatitis A virus inhibits cellular antiviral defense mechanisms induced by double-stranded RNA.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Redefining the immune landscape of hepatitis A virus infection.Experimental & molecular medicine · 2025Review
- Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion.Frontiers in microbiology · 2021Review
- Co-Occurrence of Hepatitis A Infection and Chronic Liver Disease.International journal of molecular sciences · 2020Review
- Induction and Suppression of Innate Antiviral Responses by Hepatitis A Virus.Frontiers in microbiology · 2018Review
- Solubility as a limiting factor for expression of hepatitis A virus proteins in insect cell-baculovirus system.Memorias do Instituto Oswaldo Cruz · 2016Article
- Regulation of RIG-I-like receptor signaling by host and viral proteins.Cytokine & growth factor reviews · 2014Review
- Molecular biology and inhibitors of hepatitis A virus.Medicinal research reviews · 2014Review
- Identification and validation of a novel microRNA-like molecule derived from a cytoplasmic RNA virus antigenome by bioinformatics and experimental approaches.Virology journal · 2014Article
- Innate and adaptive immune responses against picornaviruses and their counteractions: An overview.World journal of virology · 2012Review
- Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Poly(A) binding protein, C-terminally truncated by the hepatitis A virus proteinase 3C, inhibits viral translation.Nucleic acids research · 2007Article
- Silencing of hepatitis A virus infection by small interfering RNAs.Journal of virology · 2006Article
- Hepatitis A virus suppresses RIG-I-mediated IRF-3 activation to block induction of beta interferon.Journal of virology · 2005Article
- Apoptosis induced by a cytopathic hepatitis A virus is dependent on caspase activation following ribosomal RNA degradation but occurs in the absence of 2'-5' oligoadenylate synthetase.Antiviral research · 2004Article
- Classical swine fever virus interferes with cellular antiviral defense: evidence for a novel function of N(pro).Journal of virology · 2003Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The consequences of a hepatitis A virus (HAV) infection on cell-based antiviral responses and the interactions between virus and host cells resulting in persistent infections are poorly understood. In this report, we show that HAV does inhibit double-stranded (dsRNA)-induced beta interferon (IFN-beta) gene expression by influencing the IFN-beta enhanceosome, as well as dsRNA-induced apoptosis, which suggests that both effects may be connected by shared viral and/or cellular factors. This ability of HAV, which preserves the sites of virus production for a longer time, may allow the virus to establish an infection and may be the presupposition for setting up persistent infections. Our results suggest that the inhibitory effect of HAV on the cellular defense mechanisms might not be sufficient to completely prevent the antiviral reactions, which may be induced by accumulating viral dsRNA, at a later stage of infection. However, HAV seems to counteract this situation by downregulation of viral replication and in the following production of viral dsRNA. This ability of noncytopathogenic HAV acts dominantly on cytopathogenic HAV in trans. The downregulation might ensure the moderate replication which seems necessary for inhibition of the antiviral mechanisms by HAV and therefore for the persistent state of the HAV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.