Evidence map›Paper›PMID 12414779›Full record

ArticleClinical and diagnostic laboratory immunology2002

Use of a single monoclonal antibody to determine the susceptibilities of herpes simplex virus type 1 and type 2 clinical isolates to acyclovir.

Christine Chutkowski, Betty Olson, Ann McDonough, James Mahoney, James J McSharry

Abstract read
In one paragraph

Article in Clinical and diagnostic laboratory immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Antiviral activities of extracts from Hong Kong seaweeds.Journal of Zhejiang University. Science. B · 2008
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christine ChutkowskiCenter for Immunology and Microbial Disease, Albany Medical Center, Albany, New York 12208, USA.
Betty Olson
Ann McDonough
James Mahoney
James J McSharry

Funding

FACS ANALYSIS OF ANTIVIRAL DRUGS ON HCMV REPLICATIONR03AI045350 · NIAID · ALBANY MEDICAL COLLEGE · PI MCSHARRY, JAMES · 1999 to 2000
$78k
NIAID NIH HHS R03-AI45350
6 · The paper itself

Abstract

This report describes a flow cytometry drug susceptibility assay that uses a single fluorochrome-labeled monoclonal antibody to determine the acyclovir susceptibilities of herpes simplex virus (HSV) type 1 or type 2 clinical isolates. This assay yields 50% effective doses (drug concentrations that reduce the number of antigen-positive cells by 50%) for HSV clinical isolates that are equivalent to those obtained with the plaque reduction assay.

Indexed as

AcyclovirAntibodies, MonoclonalAntigens, ViralAntiviral AgentsFlow CytometryFluorescent DyesHerpesvirus 1, HumanHerpesvirus 2, HumanHumansMicrobial Sensitivity TestsAcyclovirAntibodies, MonoclonalAntigens, ViralAntiviral AgentsFluorescent Dyes

Identifiers

PMID12414779
PMCPMC130122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.