ArticleBiophysical journal2002
Depletion-mediated red blood cell aggregation in polymer solutions.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Application of blood rheology to develop hemolysis-free serum extraction sampling method for small-volume blood.Practical laboratory medicine · 2026Article
- Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage.Blood advances · 2025Article
- Aggregation and disaggregation of red blood cells: Depletion versus bridging.Biophysical journal · 2025Article
- The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms.The Biochemical journal · 2024Review
- Competition between deformation and free volume quantified by 3D image analysis of red blood cell.Biophysical journal · 2023Article
- Influence of storage and buffer composition on the mechanical behavior of flowing red blood cells.Biophysical journal · 2023Article
- Relationship between red blood cell aggregation and dextran molecular mass.Scientific reports · 2022Article
- Red Blood Cell Sedimentation Index Using Shear Stress of Blood Flow in Microfluidic Channel.Biosensors · 2022Article
- Recent Advances in Computational Modeling of Biomechanics and Biorheology of Red Blood Cells in Diabetes.Biomimetics (Basel, Switzerland) · 2022Article
- A mechanistic model of cross-bridge migration in RBC aggregation and disaggregation.Frontiers in bioengineering and biotechnology · 2022Article
- Physical Properties of Blood and their Relationship to Clinical Conditions.Frontiers in physiology · 2022Review
- Local hemodynamic analysis after coronary stent implantation based on Euler-Lagrange method.Journal of biological physics · 2021Article
- Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow.Scientific reports · 2021Article
- Advanced Constitutive Modeling of the Thixotropic Elasto-Visco-Plastic Behavior of Blood: Description of the Model and Rheological Predictions.Materials (Basel, Switzerland) · 2020Article
- Quantifying Fibrinogen-Dependent Aggregation of Red Blood Cells in Type 2 Diabetes Mellitus.Biophysical journal · 2020Article
- Optical Tweezers in Studies of Red Blood Cells.Cells · 2020Article
- Influence of Pulsed He-Ne Laser Irradiation on the Red Blood Cell Interaction Studied by Optical Tweezers.Micromachines · 2019Article
- Potential Diagnostic Hemorheological Indexes for Chronic Kidney Disease in Patients With Type 2 Diabetes.Frontiers in physiology · 2019Review
- Extended photoacoustic transport model for characterization of red blood cell morphology in microchannel flow.Biomedical optics express · 2018Article
- Dextran adsorption onto red blood cells revisited: single cell quantification by laser tweezers combined with microfluidics.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Polymer-induced red blood cell (RBC) aggregation is of current basic science and clinical interest, and a depletion-mediated model for this phenomenon has been suggested; to date, however, analytical approaches to this model are lacking. An approach is thus described for calculating the interaction energy between RBC in polymer solutions. The model combines electrostatic repulsion due to RBC surface charge with osmotic attractive forces due to polymer depletion near the RBC surface. The effects of polymer concentration and polymer physicochemical properties on depletion layer thickness and on polymer penetration into the RBC glycocalyx are considered for 40 to 500 kDa dextran and for 18 to 35 kDa poly (ethylene glycol). The calculated results are in excellent agreement with literature data for cell-cell affinities and with RBC aggregation-polymer concentration relations. These findings thus lend strong support to depletion interactions as the basis for polymer-induced RBC aggregation and suggest the usefulness of this approach for exploring interactions between macromolecules and the RBC glycocalyx.
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