ArticleBiophysical journal2002
Molecular dynamics simulation of spontaneous membrane fusion during a cubic-hexagonal phase transition.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Fusogenic Liposomes for the Intracellular Delivery of Phosphocreatine.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Curvature Energetics Determined by Alchemical Simulation on Four Topologically Distinct Lipid Phases.The journal of physical chemistry. B · 2021Article
- Structural Transitions in Ceramide Cubic Phases during Formation of the Human Skin Barrier.Biophysical journal · 2018Article
- Membrane phase transition during heating and cooling: molecular insight into reversible melting.European biophysics journal : EBJ · 2018Article
- Investigation of the morphological transition of a phospholipid bilayer membrane in an external electric field via molecular dynamics simulation.Journal of molecular modeling · 2017Article
- A tool for the morphological analysis of mixtures of lipids and water in computer simulations.Journal of molecular modeling · 2011Article
- Direct simulation of protein-mediated vesicle fusion: lung surfactant protein B.Biophysical journal · 2010Article
- Dynamics of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I.Biochemistry · 2009Article
- Modeling kinetics of subcellular disposition of chemicals.Chemical reviews · 2009Review
- Effect of trehalose on a phospholipid membrane under mechanical stress.Biophysical journal · 2008Article
- Mechanics of membrane fusion.Nature structural & molecular biology · 2008Review
- Molecular dynamics simulations of ternary membrane mixture: phosphatidylcholine, phosphatidic acid, and cholesterol.The journal of physical chemistry. B · 2007Article
- Neuronal SNAREs do not trigger fusion between synthetic membranes but do promote PEG-mediated membrane fusion.Biophysical journal · 2006Article
- Molecular view of hexagonal phase formation in phospholipid membranes.Biophysical journal · 2004Article
- Molecular dynamics simulations of the lipid bilayer edge.Biophysical journal · 2004Article
- Energetics of vesicle fusion intermediates: comparison of calculations with observed effects of osmotic and curvature stresses.Biophysical journal · 2004Article
- Molecular dynamics simulations of lipid bilayers: major artifacts due to truncating electrostatic interactions.Biophysical journal · 2003Article
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Authors and funding
2 authors.
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Abstract
We report a molecular dynamics simulation of the phase transition of monoolein from an inverted cubic phase to an inverted hexagonal phase. The transition proceeds via an intermediate structure consisting of water channels in a cubic geometry, in agreement with the predictions of the modified stalk theory (Siegel, 1999). Two mechanisms are identified by which the topology changes during the transition. Bilayer fusion proceeds via the formation of trans-monolayer contacts, whereas bilayer rupture is observed as a gradual thinning of each monolayer.
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