ArticleThe Journal of physiology2002
Membrane properties of an unusual intrinsically oscillating, wide-field teleost retinal amacrine cell.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Potential contributions of the intrinsic retinal oscillations recording using non-invasive electroretinogram to bioelectronics.Frontiers in cellular neuroscience · 2023Article
- Preventable risk factors for type 2 diabetes can be detected using noninvasive spontaneous electroretinogram signals.PloS one · 2023Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- μ-Opioid Receptor Activation Directly Modulates Intrinsically Photosensitive Retinal Ganglion Cells.Neuroscience · 2019Article
- Retinal Remodeling: Concerns, Emerging Remedies and Future Prospects.Frontiers in cellular neuroscience · 2016Article
- Origins of spontaneous activity in the degenerating retina.Frontiers in cellular neuroscience · 2015Review
- An intrinsic neural oscillator in the degenerating mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Inputs underlying the ON-OFF light responses of type 2 wide-field amacrine cells in TH::GFP mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Zebrafish Tg(7.2mab21l2:EGFP)ucd2 transgenics reveal a unique population of retinal amacrine cells.Investigative ophthalmology & visual science · 2011Article
- A central pacemaker that underlies the production of seasonal and sexually dimorphic social signals: anatomical and electrophysiological aspects.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2011Article
- Neuronal functional diversity and collective behaviors: a scientific case.Cognitive processing · 2009Review
- Neuronal functional diversity and collective behaviors.Journal of biological physics · 2008Article
- Synaptic regulation of the light-dependent oscillatory currents in starburst amacrine cells of the mouse retina.Journal of neurophysiology · 2008Article
- Light-induced changes in spike synchronization between coupled ON direction selective ganglion cells in the mammalian retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Spontaneous activity of dopaminergic retinal neurons.Biophysical journal · 2003Article
- A high frequency resonance in the responses of retinal ganglion cells to rapidly modulated stimuli: a computer model.Visual neuroscienceArticle
- A model of high-frequency oscillatory potentials in retinal ganglion cells.Visual neuroscienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
In the retina, amacrine cells modulate the transfer of information from bipolar to ganglion cells. The nature of the modulation depends on the synaptic input and the membrane properties of the cells. In the retina of white bass, we identified a class of bistratified, wide-field amacrine cell characterized by immunopositive labelling for GABA and calmodulin. In isolation, the cells presented resting membrane potentials averaging -69 mV although some cells settled at more depolarized values (-30 mV). Injection of depolarizing current pulses induced oscillatory membrane responses. When elicited from depolarized cells, the oscillations were short-lived (< 40 ms). For the most part, the oscillatory potentials of hyperpolarized cells remained unattenuated throughout the depolarizing pulse. The frequency of the oscillations increased logarithmically with mean membrane potential, ranging from 74 to 140 Hz. Cells exhibiting depolarized membrane potentials oscillated at twice that rate. When the membrane potential of these cells was hyperpolarized to -70 mV, the oscillations became unattenuated and slowed. We found the cells expressed voltage-gated sodium, potassium and calcium currents and calcium-dependent potassium currents. We demonstrate that the oscillatory potentials arose as a result of the interplay between calcium and potassium currents. The cells responded to local application of GABA and glycine, both of which modulate the oscillatory potentials. Glutamate and its analogues depolarized the cell and induced oscillatory potentials. Our results indicate that oscillatory responses of a type of wide-field amacrine cell are an intrinsic feature of the cell and not due to circuit properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.