ArticleThe EMBO journal2002
Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- HP1β and H3K9me3 Regulate Olfactory Receptor Choice and Transcriptional Identity.bioRxiv : the preprint server for biology · 2025Article
- The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts.Nature genetics · 2021Article
- Heterochromatin protein 1 (HP1): interactions with itself and chromatin components.Biophysical reviews · 2020Review
- β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming.PLoS genetics · 2018Article
- Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease.Human molecular genetics · 2018Article
- CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.Nucleic acids research · 2017Article
- Article
- Glucocorticoid Receptor Transcriptional Activation via the BRG1-Dependent Recruitment of TOP2β and Ku70/86.Molecular and cellular biology · 2015Article
- Identification of protein complexes that bind to histone H3 combinatorial modifications using super-SILAC and weighted correlation network analysis.Nucleic acids research · 2015Article
- Beyond the histone tale: HP1α deregulation in breast cancer epigenetics.Cancer biology & therapy · 2015Review
- LIA4 encodes a chromoshadow domain protein required for genomewide DNA rearrangements in Tetrahymena thermophila.Eukaryotic cell · 2014Article
- Interplay between Epigenetics and Genetics in Cancer.Genomics & informatics · 2013Review
- Diverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approaches.PLoS genetics · 2011Article
- Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1 (HP1).The Journal of biological chemistry · 2010Article
- The role of epigenetics in the pathology of diabetic complications.American journal of physiology. Renal physiology · 2010Review
- Epigenetics of diabetic complications.Expert review of endocrinology & metabolism · 2010Article
- Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression.PLoS genetics · 2009Article
- Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications.Molecular & cellular proteomics : MCP · 2009Article
- Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Heterochromatin protein 1 is recruited to various types of DNA damage.The Journal of cell biology · 2009Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian heterochromatin protein 1 (HP1) alpha, HP1beta and HP1gamma are closely related non-histone chromosomal proteins that function in gene silencing, presumably by organizing higher order chromatin structures. Here, we show by co-immunoprecipitation that HP1alpha, but neither HP1beta nor HP1gamma, forms a complex with the BRG1 chromatin-remodeling factor in HeLa cells. In vitro, BRG1 interacts directly and preferentially with HP1alpha. The region conferring this preferential binding has been mapped to residues 106-180 of the HP1alpha C-terminal chromoshadow domain. Using site-directed mutagenesis, we have identified three amino acid residues I113, A114 and C133 in HP1alpha (K, P and S in HP1beta and HP1gamma) that are essential for the selective interaction of HP1alpha with BRG1. Interestingly, these residues were also shown to be critical for the silencing activity of HP1alpha. Taken together, these results demonstrate that mammalian HP1 proteins are biochemically distinct and suggest an entirely novel function for BRG1 in modulating HP1alpha-containing heterochromatic structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.