ArticleBritish journal of pharmacology2002
Anandamide induces cough in conscious guinea-pigs through VR1 receptors.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 80 citations in OpenAlex.
- Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker.British journal of pharmacology · 2021Article
- Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets.Annals of the New York Academy of Sciences · 2020Article
- Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Dissecting the Physiology and Pathophysiology of Glucagon-Like Peptide-1.Frontiers in endocrinology · 2018Review
- Targeting TRP channels for chronic cough: from bench to bedside.Naunyn-Schmiedeberg's archives of pharmacology · 2015Review
- Transient receptor potential (TRP) channels in the airway: role in airway disease.British journal of pharmacology · 2014Review
- Pre-clinical studies in cough research: role of Transient Receptor Potential (TRP) channels.Pulmonary pharmacology & therapeutics · 2013Review
- Molecular signaling and targets from itch: lessons for cough.Cough (London, England) · 2013Article
- Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures.Proceedings of the American Thoracic Society · 2010Review
- Afferent nerves regulating the cough reflex: mechanisms and mediators of cough in disease.Otolaryngologic clinics of North America · 2010Review
- Bronchodilator effect of deep inspiration and bronchoconstriction-triggered cough.Cough (London, England) · 2009Article
- Central mechanisms II: pharmacology of brainstem pathways.Handbook of experimental pharmacology · 2009Review
- Sensory nerves and airway irritability.Handbook of experimental pharmacology · 2009Review
- Cough sensors. I. Physiological and pharmacological properties of the afferent nerves regulating cough.Handbook of experimental pharmacology · 2009Review
- Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.Physiology (Bethesda, Md.) · 2008Review
- Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids.British journal of pharmacology · 2008Article
- Review
- TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs.Cough (London, England) · 2006Article
- Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice.Cough (London, England) · 2006Article
- Comparison of cough reflex sensitivity after an inhaled antigen challenge between actively and passively sensitized guinea pigs.Cough (London, England) · 2005Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Endogenous neuronal lipid mediator anandamide, which can be synthesized in the lung, is a ligand of both cannabinoid (CB) and vanilloid receptors (VR). The tussigenic effect of anandamide has not been studied. The current study was designed to test the direct tussigenic effect of anandamide in conscious guinea-pigs, and its effect on VR1 receptor function in isolated primary guinea-pig nodose ganglia neurons. 2. Anandamide (0.3-3 mg.ml(-1)), when given by aerosol, induced cough in conscious guinea-pigs in a concentration dependent manner. When guinea-pigs were pretreated with capsazepine, a VR1 antagonist, the anandamide-induced cough was significantly inhibited. Pretreatment with CB1 (SR 141716A) and CB2 (SR 144528) antagonists had no effect on anandamide-induced cough. These results indicate that anandamide-induced cough is mediated through the activation of VR1 receptors. 3. Anandamide (10-100 micro M) increased intracellular Ca(2+) concentration estimated by Fluo-4 fluorescence change in isolated guinea-pig nodose ganglia cells. The anandamide-induced Ca(2+) response was inhibited by two different VR1 antagonists: capsazepine (1 micro M) and iodo-resiniferatoxin (I-RTX, 0.1 micro M), indicating that anandamide-induced Ca(2+) response was through VR1 channel activation. In contrast, the CB1 (SR 141716A, 1 micro M) and CB2 (SR 144528, 0.1 micro M) receptor antagonists had no effect on Ca(2+) response to anandamide. 4. In conclusion, these results provide evidence that anandamide activates native vanilloid receptors in isolated guinea-pig nodose ganglia cells and induces cough through activation of VR1 receptors.
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