ArticleProceedings of the National Academy of Sciences of the United States of America2002
Molecular characterization of mouse gastric epithelial progenitor cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 96 citations in OpenAlex.
- The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation.The Journal of biological chemistry · 2013Trial
- Single-cell transcriptomic analysis reveals crucial oncogenic signatures and its associative cell types involved in gastric cancer.Medical oncology (Northwood, London, England) · 2023Article
- Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis.Nature communications · 2023Article
- The EJC component Magoh in non-vertebrate chordates.Development genes and evolution · 2020Article
- Pathobiology of Helicobacter pylori-Induced Gastric Cancer.Gastroenterology · 2016Review
- Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer.The Journal of pathology · 2015Article
- In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.Gastroenterology · 2015Article
- Gastric cancer stem cells: a novel therapeutic target.Cancer letters · 2013Review
- Complementary expression and repulsive signaling suggest that EphB receptors and ephrin-B ligands control cell positioning in the gastric epithelium.Histochemistry and cell biology · 2011Article
- Selective gene expression by rat gastric corpus epithelium.Physiological genomics · 2011Article
- Gastric epithelial stem cells.Gastroenterology · 2011Review
- Stem cells and cancer of the stomach and intestine.Molecular oncology · 2010Review
- Developmental expression of Eph and ephrin family genes in mammalian small intestine.Digestive diseases and sciences · 2010Article
- RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.Molecular and cellular biology · 2010Article
- How form follows functional genomics: gene expression profiling gastric epithelial cells with a particular discourse on the parietal cell.Physiological genomics · 2009Review
- The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage.Developmental biology · 2009Article
- Amplification and invasiveness of epithelial progenitors during gastric carcinogenesis in trefoil factor 1 knockout mice.Cell proliferation · 2008Article
- Diverse adult stem cells share specific higher-order patterns of gene expression.Stem cells (Dayton, Ohio) · 2008Article
- Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Helicobacter pylori: present status and future prospects in Japan.Journal of gastroenterology · 2007Review
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5 authors at 1 institution in 1 country.
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Abstract
The adult mouse gastric epithelium undergoes continuous renewal in discrete anatomic units. Lineage tracing studies have previously disclosed the morphologic features of gastric epithelial lineage progenitors (GEPs), including those of the presumptive multipotent stem cell. However, their molecular features have not been defined. Here, we present the results of an analysis of genes and pathways expressed in these cells. One hundred forty-seven transcripts enriched in GEPs were identified using an approach that did not require physical disruption of the stem cell niche. Real-time quantitative RT-PCR studies of laser capture microdissected cells retrieved from this niche confirmed enriched expression of a selected set of genes from the GEP list. An algorithm that allows quantitative comparisons of the functional relatedness of automatically annotated expression profiles showed that the GEP profile is similar to a dataset of genes that defines mouse hematopoietic stem cells, and distinct from the profiles of two differentiated GEP descendant lineages (parietal and zymogenic cell). Overall, our analysis revealed that growth factor response pathways are prominent in GEPs, with insulin-like growth factor appearing to play a key role. A substantial fraction of GEP transcripts encode products required for mRNA processing and cytoplasmic localization, including numerous homologs of Drosophila genes (e.g., Y14, staufen, mago nashi) needed for axis formation during oogenesis. mRNA targeting proteins may help these epithelial progenitors establish differential communications with neighboring cells in their niche.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.