ArticleOccupational and environmental medicine2002
Exposure-response analysis and risk assessment for silica and silicosis mortality in a pooled analysis of six cohorts.
Article in Occupational and environmental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Relationship between cumulative silica exposure and silicosis: a systematic review and dose-response meta-analysis.Thorax · 2024Pooled it
- Risk Assessment of Silicosis and Lung Cancer Mortality associated with Occupational Exposure to Crystalline Silica in Iran.Journal of research in health sciences · 2022Pooled it
- Silicosis Surveillance in California, 2019-2024: Tracking an Epidemic.American journal of public health · 2025Article
- Assessment of Cancer Rate in Mine Workers Exposed to Crystalline Silica.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety.Frontiers in toxicology · 2025Article
- A combination of silica and cigarette smoke extract exacerbates lung fibrosis: Unveiling a harmful synergy.PloS one · 2025Article
- Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis: a national prospective follow-up study.Occupational and environmental medicine · 2024Article
- Article
- Silicosis Incidence and Mortality after Occupational Exposure with Silica Dust: A Systematic Review and Dose-Response Meta-Analysis.Medical journal of the Islamic Republic of Iran · 2024Review
- Application of Multiple Occupational Health Risk Assessment Models for Crystalline Silica Dust among Stone Carvers.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Underdiagnosis of silicosis revealed by reinterpretation of chest radiographs in Thai ceramic workers.Multidisciplinary respiratory medicine · 2023Article
- Silicosis, tuberculosis and silica exposure among artisanal and small-scale miners: A systematic review and modelling paper.PLOS global public health · 2023Article
- A toxicological profile of silica nanoparticles.Toxicology research · 2022Review
- Determinants of Respirable Quartz Exposure Concentrations Across Occupations in Denmark, 2018.Annals of work exposures and health · 2022Article
- Premature Deaths Due to Silicosis in Turkey, 2006-2017: A Twelve-Year Longitudinal Study.Balkan medical journal · 2021Article
- Association between Crystalline Silica Dust Exposure and Silicosis Development in Artificial Stone Workers.International journal of environmental research and public health · 2021Article
- Extracellular signal-regulated kinase signaling pathway and silicosis.Toxicology research · 2021Review
- Association of Silica Dust Exposure and Cigarette Smoking With Mortality Among Mine and Pottery Workers in China.JAMA network open · 2020Article
- Oxidative potential (OP) and mineralogy of iron ore particulate matter at the Gol-E-Gohar Mining and Industrial Facility (Iran).Environmental geochemistry and health · 2018Article
- Estimating the Impact of Changes to Occupational Standards for Silica Exposure on Lung Cancer Mortality.Epidemiology (Cambridge, Mass.) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo study the relation between exposure to crystalline silica and silicosis mortality. Although mortality is an important endpoint for regulators, there have been no exposure-response studies for silicosis mortality, because of the relative rareness of silicosis as an underlying cause of death, and the limited availability of quantitative exposure estimates.
methodsData from six occupational cohorts were pooled with good retrospective exposure data in which 170 deaths from silicosis were reported. Standard life table analyses, nested case-control analyses, and risk assessment were performed.
resultsThe rate of silicosis mortality in the combined data was 28/100 000 py, increasing in nearly monotonic fashion from 4.7/100 000 for exposure of 0-0.99 mg/m(3)-years to 233/100 000 for exposure of >28.1 mg/m(3)-years. The estimated risk of death up to age 65 from silicosis after 45 years of exposure at 0.1 mg/m(3) silica (the current standard in many countries) was 13 per 1000, while the estimated risk at an exposure of 0.05 mg/m(3) was 6 per 1000. Both of these risks are above the risk of 1 per 1000 typically deemed acceptable by the US OSHA.
conclusionThe findings from this pooled analysis add further support to the need to control silica exposure and to lower the occupational standards. Our estimates of lifetime silicosis mortality risk are probably underestimates as, in addition to exposure misclassification, our study might have suffered from outcome misclassification in that silicosis deaths might have been coded to other related causes, such as tuberculosis or chronic obstructive pulmonary disease.
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