ArticleNucleic acids research2002
An analysis of the sequence requirements of EDEN-BP for specific RNA binding.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 26 citations in OpenAlex.
- A genome-wide survey of maternal and embryonic transcripts during Xenopus tropicalis development.BMC genomics · 2013Article
- Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1.Nucleic acids research · 2013Article
- Bioinformatic identification of novel elements potentially involved in messenger RNA fate control during spermatogenesis.Biology of reproduction · 2012Article
- Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N--terminal RRMs of CELF1.Nucleic acids research · 2011Article
- SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing.Molecular and cellular biology · 2009Article
- Translational control of maskin mRNA by its 3' untranslated region.Biology of the cell · 2007Article
- CUG-BP1/CELF1 requires UGU-rich sequences for high-affinity binding.The Biochemical journal · 2006Article
- CUG-BP binds to RNA substrates and recruits PARN deadenylase.RNA (New York, N.Y.) · 2006Article
- Identification of putative new splicing targets for ETR-3 using sequences identified by systematic evolution of ligands by exponential enrichment.Molecular and cellular biology · 2005Article
- Identification of CELF splicing activation and repression domains in vivo.Nucleic acids research · 2005Article
- ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo.Nucleic acids research · 2004Article
- The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element.Nucleic acids research · 2004Article
- CELFish ways to modulate mRNA decay.Biochimica et biophysica actaReview
- The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins.Wiley interdisciplinary reviews. RNAReview
- Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EDEN-BP (embryo deadenylation element-binding protein) binds specifically to the EDEN motif in the 3'-untranslated regions of maternal mRNAs and targets these mRNAs for deadenylation and translational repression in Xenopus laevis embryos. EDEN-BP contains three RNA recognition motifs (RRMs) and is related to the elav family of RNA-binding proteins. In the present study we show that the two N-terminal RRMs of EDEN-BP are necessary for the interaction with EDEN as well as a part of the linker region (between RRM2 and RRM3). Using a band shift assay we show that two different complexes are formed according to the size and, therefore, the functional nature of the EDEN motif. Finally, we show that EDEN-BP can form a dimer in a two-hybrid assay. Accordingly, we suggest that the functional configuration of EDEN-BP is a dimer.
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