ArticleNucleic acids research2002
In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 127 citations in OpenAlex.
- Stiff matrix-induced KRTAP2-3 expression suppresses ciliogenesis via actin tension-driven chromatin remodeling.Cell death & disease · 2026Article
- The dual guardians of cellular stability: exploring nesprin and lamin in senescence.Cell death & disease · 2025Review
- The Role of Emerin in Cancer Progression and Metastasis.International journal of molecular sciences · 2021Review
- Gravitational Force-Induced 3D Chromosomal Conformational Changes Are Associated with Rapid Transcriptional Response in Human T Cells.International journal of molecular sciences · 2021Article
- Nuclear lamin A in rotator cuff tear margin tenocytes: an antiapoptotic and cell mechanostat factor.Journal of orthopaedic surgery and research · 2021Article
- Muscle Enriched Lamin Interacting Protein (Cells · 2021Article
- Lamin A/C Mechanotransduction in Laminopathies.Cells · 2020Review
- Molecular-Level Interactions between Engineered Materials and Cells.International journal of molecular sciences · 2019Review
- Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus.BMC molecular and cell biology · 2019Article
- Dynamic regulation of nuclear architecture and mechanics-a rheostatic role for the nucleus in tailoring cellular mechanosensitivity.Nucleus (Austin, Tex.) · 2017Review
- Ameliorating pathogenesis by removing an exon containing a missense mutation: a potential exon-skipping therapy for laminopathies.Gene therapy · 2015Article
- Phosphorylation of lamins determine their structural properties and signaling functions.Nucleus (Austin, Tex.) · 2015Article
- Interphase phosphorylation of lamin A.Journal of cell science · 2014Article
- Single nucleotide polymorphisms associated with colorectal cancer susceptibility and loss of heterozygosity in a Taiwanese population.PloS one · 2014Article
- Partners and post-translational modifications of nuclear lamins.Chromosoma · 2013Review
- Mechanosensitive mechanisms in transcriptional regulation.Journal of cell science · 2012Review
- CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy.Circulation research · 2012Article
- The functions of the nuclear envelope in mediating the molecular crosstalk between the nucleus and the cytoplasm.Current opinion in cell biology · 2012Review
- Lamin A, farnesylation and aging.Experimental cell research · 2012Review
- Cytoskeletal interactions at the nuclear envelope mediated by nesprins.International journal of cell biology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human and murine MOK2 proteins are factors able to recognize both DNA and RNA through their zinc finger motifs. This dual affinity of MOK2 suggests that MOK2 might be involved in transcription and post-transcriptional regulation of MOK2 target genes. The IRBP gene contains two MOK2-binding elements, a complete 18 bp MOK2-binding site located in intron 2 and the essential core MOK2-binding site (8 bp of conserved 3'-half-site) located in the IRBP promoter. We have demonstrated that MOK2 can bind to the 8 bp present in the IRBP promoter and repress transcription from this promoter by competing with the CRX activator for DNA binding. In this study, we identify a novel interaction between lamin A/C and hsMOK2 by using the yeast two-hybrid system. The interaction, which was confirmed by GST pull-down assays and co-immunolocalization studies in vivo, requires the N-terminal acidic domain of hsMOK2 and the coiled 2 domain of lamin A/C. Furthermore, we show that a fraction of hsMOK2 protein is associated with the nuclear matrix. We therefore suggest that hsMOK2 interactions with lamin A/C and the nuclear matrix may be important for its ability to repress transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.