ArticleNucleic acids research2002
A versatile communication module for controlling RNA folding and catalysis.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- From peptides to DNA: All required steps can be catalyzed.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Apollon: a deoxyribozyme that generates a yellow product.Nucleic acids research · 2024Article
- Cell-free transcription-translation system: a dual read-out assay to characterize riboswitch function.Nucleic acids research · 2023Article
- Riboswitches for Controlled Expression of Therapeutic Transgenes Delivered by Adeno-Associated Viral Vectors.Pharmaceuticals (Basel, Switzerland) · 2021Review
- RNA Fluorescence with Light-Up Aptamers.Frontiers in chemistry · 2016Review
- Controlling mammalian gene expression by allosteric hepatitis delta virus ribozymes.ACS synthetic biology · 2013Article
- Modulating RNA structure and catalysis: lessons from small cleaving ribozymes.Cellular and molecular life sciences : CMLS · 2009Review
- Engineering ligand-responsive gene-control elements: lessons learned from natural riboswitches.Gene therapy · 2009Review
- A modular and extensible RNA-based gene-regulatory platform for engineering cellular function.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Bis-aptazyme sensors for hepatitis C virus replicase and helicase without blank signal.Nucleic acids research · 2005Article
- Competitive regulation of modular allosteric aptazymes by a small molecule and oligonucleotide effector.RNA (New York, N.Y.) · 2005Article
- A general method for rapid and nondenaturing purification of RNAs.RNA (New York, N.Y.) · 2004Article
- A novel strategy for selection of allosteric ribozymes yields RiboReporter sensors for caffeine and aspartame.Nucleic acids research · 2004Article
- Rube Goldberg goes (ribo)nuclear? Molecular switches and sensors made from RNA.RNA (New York, N.Y.) · 2003Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To exert control over RNA folding and catalysis, both molecular engineering strategies and in vitro selection techniques have been applied toward the development of allosteric ribozymes whose activities are regulated by the binding of specific effector molecules or ligands. We now describe the isolation and characterization of a new and considerably versatile RNA element that functions as a communication module to render disparate RNA folding domains interdependent. In contrast to some existing communication modules, the novel 9-nt RNA element is demonstrated to function similarly between a variety of catalysts that include the hepatitis delta virus, hammerhead, X motif and Tetrahymena group I ribozymes, and various ligand-binding domains. The data support a mechanistic model of RNA folding in which the element is comprised of both canonical and non-canonical base pairs and an unpaired nucleotide in the active, effector-bound conformation. Aside from enabling effector-controlled RNA function through rational design, the element can be utilized to identify sites in large RNAs that are susceptible to effector regulation.
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