ArticleJournal of clinical microbiology2002
Identification of the causative organism of tuberculous lymphadenitis in ethiopia by PCR.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Global prevalence of Mycobacterium bovis infections among human tuberculosis cases: Systematic review and meta-analysis.Zoonoses and public health · 2021Pooled it
- Epidemiology of tuberculous lymphadenitis in Africa: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Genetic diversity of Mycobacterium bovis in dairy products and cattle tissues from northwest Iran using a 12-locus MIRU-VNTR approach.Scientific reports · 2026Article
- Bovine tuberculosis in cattle slaughtered at Addis Ababa abattoir in Ethiopia and workforce awareness of zoonotic risk.PloS one · 2025Article
- Zoonotic transmission of theFrontiers in veterinary science · 2025Article
- Bovine tuberculosis in Central Ethiopian slaughterhouses and the identification of causative mycobacteria by multiplex real-time PCR.BMC microbiology · 2024Article
- Comparative Diagnostic of Cervical Tuberculous Lymphadenitis: PCR is a Fast, Efficient, and Improved Diagnostic Approach.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Article
- Genetic diversity and drug resistance profiles ofIJID regions · 2022Article
- Public Awareness, Prevalence and Potential Determinants of Bovine Tuberculosis in Selected Districts of Gamo Zone, Southern Ethiopia.Veterinary medicine (Auckland, N.Z.) · 2022Article
- Pathological, Histological, and Molecular Based Investigations Confirm NovelBioMed research international · 2022Article
- Histopathological Investigations and Molecular Confirmation RevealBioMed research international · 2022Article
- Prevalence of bovine tuberculosis and distribution of tuberculous lesions in cattle slaughtered at Gondar, Northwest Ethiopia.Infection ecology & epidemiology · 2021Article
- Broad diversity of Mycobacterium tuberculosis complex strains isolated from humans and cattle in Northern Algeria suggests a zoonotic transmission cycle.PLoS neglected tropical diseases · 2020Article
- Bovine tuberculosis at the human-livestock-wildlife interface and its control through one health approach in the Ethiopian Somali Pastoralists: A review.One health (Amsterdam, Netherlands) · 2020Review
- Epidemiology and the diagnostic challenge of extra-pulmonary tuberculosis in a teaching hospital in Ethiopia.PloS one · 2020Article
- Risk Factors for Zoonotic Tuberculosis at the Wildlife-Livestock-Human Interface in South Africa.Pathogens (Basel, Switzerland) · 2019Article
- Evaluation of complementary diagnostic tools for bovine tuberculosis detection in dairy herds from India.Veterinary world · 2016Article
- Comparative Evaluation of Several Gene Targets for Designing a Multiplex-PCR for an Early Diagnosis of Extrapulmonary Tuberculosis.Yonsei medical journal · 2016Article
- Mycobacterium tuberculosis causing tuberculous lymphadenitis in Maputo, Mozambique.BMC microbiology · 2015Article
- Predominance of Uganda genotype of Mycobacterium tuberculosis isolated from Ugandan patients with tuberculous lymphadenitis.BMC research notes · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledTuberculous lymphadenitis (TBLN) is a common form of extrapulmonary tuberculosis with multiple differential diagnoses. Demonstration of the etiologic agent by smear microscopy or culture of fine needle aspirate (FNA) specimens is often unsuccessful. FNA specimens from 40 patients presenting at a rural health center in South Ethiopia and diagnosed as positive for TBLN on the basis of clinical and cytological criteria were analyzed for mycobacterial DNA by PCR. Thirty (75%) had cervical lymphadenitis and 11 (27.5%) were seropositive for human immunodeficiency virus (HIV). Three primer sets were initially used to identify the causative agent at the genus (antigen 85 complex), complex (IS6110 insertion sequence), and species (pncA gene and allelic variation) levels. Among the forty TBLN cases, 35 (87.5%) were positive by PCR at the genus and complex levels. Based on PCR for detection of allelic variation at position 169, 24 (68.6%) of the 35 were positive for Mycobacterium tuberculosis and 6 (17.1%) were positive for M. bovis. These six were positive in additional PCR assays using the JB21-JB22 primer set, which is highly specific for M. bovis. Five (14.1%) showed amplification for both M. tuberculosis and M. bovis with the allele-specific primer set. Cooccurrence of pyrazinamide (PZA)-sensitive and -resistant M. tuberculosis in those five cases was indicated, since all were negative in assays with the JB21-JB22 primer set. This feature was seen in 3 of 11 HIV-positive and 2 of 29 HIV-negative individuals (P < 0.001).
conclusionamong 35 PCR-positive cases of TBLN from southern Ethiopia, 29 (82.9%) were caused by M. tuberculosis and six (17.1%) were caused by M. bovis.
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