ArticleNeoplasia (New York, N.Y.)
MRI of transgene expression: correlation to therapeutic gene expression.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
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- Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion.Oncogene · 2018Article
- Imaging techniques: new avenues in cancer gene and cell therapy.Cancer gene therapy · 2017Review
- MRI Reporter Genes for Noninvasive Molecular Imaging.Molecules (Basel, Switzerland) · 2016Review
- Overexpression of the MRI Reporter Genes Ferritin and Transferrin Receptor Affect Iron Homeostasis and Produce Limited Contrast in Mesenchymal Stem Cells.International journal of molecular sciences · 2015Article
- Intracellular gene transcription factor protein-guided MRI by DNA aptamers in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- MRI reporter genes: applications for imaging of cell survival, proliferation, migration and differentiation.NMR in biomedicine · 2013Review
- MRI reveals differential effects of amphetamine exposure on neuroglia in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- In vivo non invasive molecular imaging for immune cell tracking in small animals.Immune network · 2012Article
- Magnetic resonance tumor targeting imaging using gadolinium labeled human telomerase reverse transcriptase antisense probes.Cancer science · 2012Article
- In vivo Noninvasive Small Animal Molecular Imaging.Osong public health and research perspectives · 2012Review
- Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma.Cancer research · 2011Article
- MR reporter gene imaging of endostatin expression and therapy.Molecular imaging and biology · 2010Article
- Targeting human glioma cells using HSV-1 amplicon peptide display vector.Gene therapy · 2010Article
- Molecular magnetic resonance imaging approaches used to aid in the understanding of the tissue regeneration marker Met in vivo: implications for tissue engineering.Tissue engineering. Part A · 2010Article
- MRI reporter genes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2008Review
- Non-invasive genetic imaging for molecular and cell therapies of cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2007Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic resonance imaging (MRI) can provide high-resolution 3D maps of structural and functional information, yet its use of mapping in vivo gene expression has only recently been explored. A potential application for this technology is to noninvasively image transgene expression. The current study explores the latter using a nonregulatable internalizing engineered transferrin receptor (ETR) whose expression can be probed for with a superparamagnetic Tf-CLIO probe. Using an HSV-based amplicon vector system for transgene delivery, we demonstrate that: 1) ETR is a sensitive MR marker gene; 2) several transgenes can be efficiently expressed from a single amplicon; 3) expression of each transgene results in functional gene product; and 4) ETR gene expression correlates with expression of therapeutic genes when the latter are contained within the same amplicon. These data, taken together, suggest that MRI of ETR expression can serve as a surrogate for measuring therapeutic transgene expression.
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