ArticleRNA (New York, N.Y.)2002
An active precursor in assembly of yeast nuclear ribonuclease P.
Article in RNA (New York, N.Y.), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Multi-site DMS probing reveals higher-order structure of RNA-protein complexes in living cells.Molecular cell · 2026Article
- Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P.RNA biology · 2023Article
- Article
- In vitro reconstitution and analysis of eukaryotic RNase P RNPs.Nucleic acids research · 2018Article
- M1 RNA is important for the in-cell solubility of its cognate C5 protein: Implications for RNA-mediated protein folding.RNA biology · 2015Article
- The nuclear RNA polymerase II surveillance system targets polymerase III transcripts.The EMBO journal · 2011Article
- A single Arabidopsis organellar protein has RNase P activity.Nature structural & molecular biology · 2010Article
- Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects.FEBS letters · 2010Review
- Broadening the mission of an RNA enzyme.Journal of cellular biochemistry · 2009Review
- Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release.RNA (New York, N.Y.) · 2009Article
- Footprinting analysis demonstrates extensive similarity between eukaryotic RNase P and RNase MRP holoenzymes.RNA (New York, N.Y.) · 2008Article
- RNA affinity tags for the rapid purification and investigation of RNAs and RNA-protein complexes.Methods in molecular biology (Clifton, N.J.) · 2008Article
- Human RNase P: a tRNA-processing enzyme and transcription factor.Nucleic acids research · 2007Review
- Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP.RNA (New York, N.Y.) · 2006Article
- Characterization of conserved sequence elements in eukaryotic RNase P RNA reveals roles in holoenzyme assembly and tRNA processing.RNA (New York, N.Y.) · 2005Article
- An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5.Molecular biology of the cell · 2004Article
- Alterations in the intracellular level of a protein subunit of human RNase P affect processing of tRNA precursors.Nucleic acids research · 2003Article
- Review
- Ribonuclease P: the evolution of an ancient RNA enzyme.Critical reviews in biochemistry and molecular biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The RNA-protein subunit assembly of nuclear RNase P was investigated by specific isolation and characterization of the precursor and mature forms of RNase P using an RNA affinity ligand. Pre-RNase P was as active in pre-tRNA cleavage as mature RNase P, although it contained only seven of the nine proteins found in mature RNase P. Pop3p and Rpr2p were not required for maturation of the RPR1 RNA subunit and virtually absent from pre-RNase P, implying that they are dispensable for pre-tRNA substrate recognition and cleavage. The RNase P subunit assembly is likely to occur in the nucleolus, where both precursor and mature forms of RNase P RNA are primarily localized. The results provide insight into assembly of nuclear RNase P, and suggest pre-tRNA substrate recognition is largely determined by the RNA subunit.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.