ArticleRNA (New York, N.Y.)2002
The KH domains of Xenopus Vg1RBP mediate RNA binding and self-association.
Article in RNA (New York, N.Y.), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Insulin-like Growth Factor 2 mRNA-Binding Protein 2-a Potential Link Between Type 2 Diabetes Mellitus and Cancer.The Journal of clinical endocrinology and metabolism · 2021Review
- mRNA Localization in Plant Cells.Plant physiology · 2020Review
- RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- RNA-Binding Protein RBP-P Is Required for Glutelin and Prolamine mRNA Localization in Rice Endosperm Cells.The Plant cell · 2018Article
- The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells.Stem cells international · 2018Review
- Article
- Molecular insights into the coding region determinant-binding protein-RNA interaction through site-directed mutagenesis in the heterogeneous nuclear ribonucleoprotein-K-homology domains.The Journal of biological chemistry · 2015Article
- The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon Outgrowth In Vivo.PloS one · 2015Article
- RNA-binding protein Vg1RBP regulates terminal arbor formation but not long-range axon navigation in the developing visual system.Developmental neurobiology · 2014Article
- Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?Cellular and molecular life sciences : CMLS · 2013Review
- Identification of a male-specific RNA binding protein that regulates sex-specific splicing of Bmdsx by increasing RNA binding activity of BmPSI.Molecular and cellular biology · 2010Article
- KHDC1B is a novel CPEB binding partner specifically expressed in mouse oocytes and early embryos.Molecular biology of the cell · 2010Article
- ZBP1 recognition of beta-actin zipcode induces RNA looping.Genes & development · 2010Article
- Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.Human molecular genetics · 2009Article
- Participation of Xenopus Elr-type proteins in vegetal mRNA localization during oogenesis.The Journal of biological chemistry · 2009Article
- Vg1RBP phosphorylation by Erk2 MAP kinase correlates with the cortical release of Vg1 mRNA during meiotic maturation of Xenopus oocytes.RNA (New York, N.Y.) · 2009Article
- Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding.Nature structural & molecular biology · 2009Article
- VICKZ proteins mediate cell migration via their RNA binding activity.RNA (New York, N.Y.) · 2007Article
- CRD-BP shields c-myc and MDR-1 RNA from endonucleolytic attack by a mammalian endoribonuclease.Nucleic acids research · 2007Article
- A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP.The Journal of cell biology · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Xenopus Vg1 mRNA is localized to the vegetal cortex during oogenesis in a process involving microtubules and microfilaments and proteins that specifically recognize the vegetal localization element (VLE) within the 3' untranslated region. One of the best characterized VLE-binding proteins is Vg1RBP or Vera. Primary sequence analysis of Vg1RBP and its homologs suggests that most of its open reading frame is occupied by RNA-binding modules, including two RRMs and four KH domains, arranged as three pairs of didomains. In the first detailed domain analysis of Vg1RBP, we show that the interaction of Vg1RBP with the VLE requires both KH didomains, but not the RRM didomain, and moreover that the KH didomains contribute cooperatively to RNA binding. In the full-length protein, individual KH domains display significant redundancy, and their relative importance appears to vary with the RNA target. We also demonstrate that the KH34 didomain mediates Vg1RBP self-association, which is stabilized by RNA, and occurs in vivo as well as in vitro. Altogether, our findings highlight the importance of multiple KH domains in mediating RNA-protein and protein-protein interactions in the formation of a stable complex of Vg1RBP and Vg1 mRNA.
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