ArticleRNA (New York, N.Y.)2002
A general role for splicing enhancers in exon definition.
Article in RNA (New York, N.Y.), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- The regulation and function of post-transcriptional RNA splicing.Nature reviews. Genetics · 2025Review
- Roles and mechanisms of aberrant alternative splicing in melanoma - implications for targeted therapy and immunotherapy resistance.Cancer cell international · 2024Review
- Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors.Life (Basel, Switzerland) · 2023Review
- Exonic Variants that Affect Splicing - An Opportunity for "Hidden" Mutations Causing Inherited Retinal Diseases.Advances in experimental medicine and biology · 2023Review
- Nonsense-mediated RNA decay and its bipolar function in cancer.Molecular cancer · 2021Review
- The Alter Retina: Alternative Splicing of Retinal Genes in Health and Disease.International journal of molecular sciences · 2021Review
- Splicing Genomics Events in Cervical Cancer: Insights for Phenotypic Stratification and Biomarker Potency.Genes · 2021Review
- Identification of splice defects due to noncanonical splice site or deep-intronic variants in ABCA4.Human mutation · 2019Article
- RICH2 is implicated in viraemic control of HIV-1 in black South African individuals.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2017Article
- Alternative RNA Splicing in the Pathogenesis of Liver Disease.Frontiers in endocrinology · 2017Review
- Prediction of donor splice sites using random forest with a new sequence encoding approach.BioData mining · 2016Article
- SR proteins control a complex network of RNA-processing events.RNA (New York, N.Y.) · 2015Article
- Kinetic analysis of in vitro pre-mRNA splicing in HeLa nuclear extract.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Article
- Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules.Nature structural & molecular biology · 2012Article
- A prospective study in the rational design of efficient antisense oligonucleotides for exon skipping in the DMD gene.Human gene therapy · 2012Article
- Theory on the coupled stochastic dynamics of transcription and splice-site recognition.PLoS computational biology · 2012Article
- Efficient internal exon recognition depends on near equal contributions from the 3' and 5' splice sites.Nucleic acids research · 2011Article
- Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns.RNA (New York, N.Y.) · 2010Article
- Fast ribozyme cleavage releases transcripts from RNA polymerase II and aborts co-transcriptional pre-mRNA processing.Nature structural & molecular biology · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Exonic splicing enhancers (ESEs) facilitate exon definition by assisting in the recruitment of splicing factors to the adjacent intron. Here we demonstrate that suboptimal 5' and 3' splice sites are activated independently by ESEs when they are located on different exons. However, when they are situated within a single exon, the same weak 5' and 3' splice sites are activated simultaneously by a single ESE. These findings demonstrate that a single ESE promotes the recognition of both exon/intron junctions within the same step during exon definition. Our results suggest that ESEs recruit a multicomponent complex that minimally contains components of the splicing machinery required for 5' and 3' splice site selection.
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Registered trials
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