ReviewImmunologic research2002
Varied biologic functions of C-reactive protein: lessons learned from transgenic mice.
Review in Immunologic research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Secretory quality control constrains functional selection-associated protein structure innovation.Communications biology · 2022Article
- Genetic ablation of C-reactive protein gene confers resistance to obesity and insulin resistance in rats.Diabetologia · 2021Article
- Deletion of Smad3 protects against C-reactive protein-induced renal fibrosis and inflammation in obstructive nephropathy.International journal of biological sciences · 2021Article
- Therapeutic Lowering of C-Reactive Protein.Frontiers in immunology · 2020Review
- Fevers in Adult Lupus Patients.Cureus · 2018Review
- C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance.Frontiers in immunology · 2018Article
- Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes.Frontiers in immunology · 2018Review
- Mixed effects of caffeic acid phenethyl ester (CAPE) on joint inflammation, bone loss and gastrointestinal inflammation in a murine model of collagen antibody-induced arthritis.Inflammopharmacology · 2017Article
- C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway.Scientific reports · 2016Article
- Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link.Journal of immunology research · 2016Review
- Inhibiting C-reactive protein for the treatment of cardiovascular disease: promising evidence from rodent models.Mediators of inflammation · 2014Article
- Animal models of C-reactive protein.Mediators of inflammation · 2014Review
- A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans.Molecular therapy. Nucleic acids · 2012Article
- C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.Diabetologia · 2011Article
- Collagen-induced arthritis is exacerbated in C-reactive protein-deficient mice.Arthritis and rheumatism · 2011Article
- Article
- Chronic insulin therapy reduces adipose tissue macrophage content in LDL-receptor-deficient mice.Diabetologia · 2011Article
- Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is FcγRIIB Dependent.Autoimmune diseases · 2010Article
- Serum amyloid A3 does not contribute to circulating SAA levels.Journal of lipid research · 2009Article
- Estrogen and mechanisms of vascular protection.Arteriosclerosis, thrombosis, and vascular biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Our investigations of human C-reactive protein (CRP) and CRP transgenic mice have produced novel data that firmly establish this protein as an important host defense molecule. For example, we have learned that depending on the disease model, the beneficial effect of CRP can be direct, depend on the protein's ability to engage complement and Fcy receptors, or rely on its ability to bridge innate and adaptive immunity. In addition, the degree of protection correlates with acute phase expression, but more important, also with the amount of CRP expressed constitutively. Furthermore, differences in baseline levels of CRP among healthy individuals and among patients can be attributed to a CRP gene polymorphism. In this article, we discuss these and other observations we have made during the last 5 yr and summarize our ongoing studies and future plans related to CRP biology.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.