ReviewImmunologic research2002
CD5, an important regulator of lymphocyte selection and immune tolerance.
Review in Immunologic research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- A prospective study on the regulation of osteoarthritis risk through inflammatory pathways in clonal hematopoiesis.GeroScience · 2026Article
- Single-Cell Dissection Reveals Immune Dysregulation After CD5 or CD7-Directed Chimeric Antigen Receptor T-Cell Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Associations of Air Pollution Mixture Exposure with Plasma Proteins in an Elderly U.S. Panel.Environmental science & technology · 2025Article
- CD5 Immunoreactivity Is Associated With Longer Overall Survival in Thymic Carcinoma: A Brief Report.JTO clinical and research reports · 2025Article
- Shift in the B cell subsets between children with type 1 diabetes and/or celiac disease.Clinical and experimental immunology · 2024Article
- Causal Relationships Between Circulating Inflammatory Proteins and Obstructive Sleep Apnea: A Bidirectional Mendelian Randomization Study.Nature and science of sleep · 2024Article
- Malignant and Benign T Cells Constituting Cutaneous T-Cell Lymphoma.International journal of molecular sciences · 2021Review
- The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function.Immunological reviews · 2021Review
- Predominant VH1-69 IgBCR Clones Show Higher Expression of CD5 in Heterogeneous Chronic Lymphocytic Leukemia Populations.Frontiers in oncology · 2021Article
- CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- The Plasma Interleukin (IL)-35 Level and Frequency of Circulating IL-35Scientific reports · 2019Article
- CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses.PloS one · 2019Article
- Tuning T Cell Signaling Sensitivity Alters the Behavior of CD4Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Constitutive Phosphorylation of STAT3 by the CK2-BLNK-CD5 Complex.Molecular cancer research : MCR · 2017Article
- Correlation of serum cytokines, chemokines, growth factors and enzymes with periodontal disease parameters.PloS one · 2017Article
- CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1.International journal of molecular medicine · 2016Article
- Functional Heterogeneity in CD4(+) T Cell Responses Against a Bacterial Pathogen.Frontiers in immunology · 2015Review
- T-cell modulatory properties of CD5 and its role in antitumor immune responses.Oncoimmunology · 2013Article
- Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells.Immunology and cell biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The CD5 coreceptor is a cysteine-rich scavenger receptor family glycoprotein that is expressed constitutively on all T cells and a subset of B cells (B I a B cells). It is now generally accepted that the biologic role of CD5 is to regulate intracellular strength induced by antigen receptors in both T and B cells. However, at present it is unclear if this coreceptor's effect on antigen receptor signaling is primarily costimulatory or inhibitory since support for both exists. Our studies focus on understanding the physiologic role of CD5 in the context of regulation of antigen receptor activation, B and T cell selection, and generation/maintenance of immune tolerance. In this overview, I discuss studies using experimental models of lymphocyte selection and tolerance showing that CD5 plays a key role in B and T cell selection as well as generation and maintenance of tolerance. I and others, reviewed here, now provide clear evidence that CD5 is a key regulator of immune tolerance and that alterations of its activity can promote development of autoreactivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.