ReviewImmunologic research2002
Complement in central nervous system inflammation.
Review in Immunologic research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- A Study of Acute Kidney Injury in Stroke Patients and Its Relationship to Short-term Outcome.Annals of African medicine · 2026Observational
- Neuroimmune pathways involvement in neurodegeneration of R6/2 mouse model of Huntington's disease.Frontiers in cellular neuroscience · 2024Article
- As in Real Estate, Location Matters: Cellular Expression of Complement Varies Between Macular and Peripheral Regions of the Retina and Supporting Tissues.Frontiers in immunology · 2022Article
- Systemic and cerebrospinal fluid immune and complement activation in Ugandan children and adolescents with long-standing nodding syndrome: A case-control study.Epilepsia open · 2021Article
- The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression.Scientific reports · 2019Article
- The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury.Neurotoxicity research · 2019Article
- Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System.Frontiers in immunology · 2019Review
- C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus.Immunology · 2016Article
- Soluble membrane attack complex is diagnostic for intraventricular shunt infection in children.JCI insight · 2016Article
- C5a alters blood-brain barrier integrity in a human in vitro model of systemic lupus erythematosus.Immunology · 2015Article
- Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system.Current pharmaceutical design · 2014Review
- Immune-mediated animal models of Tourette syndrome.Neuroscience and biobehavioral reviews · 2013Review
- Essential roles of gangliosides in the formation and maintenance of membrane microdomains in brain tissues.Neurochemical research · 2012Review
- C5a/CD88 signaling alters blood-brain barrier integrity in lupus through nuclear factor-κB.Journal of neurochemistry · 2011Article
- Molecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"?Journal of biomedical science · 2011Review
- The regulation of the CNS innate immune response is vital for the restoration of tissue homeostasis (repair) after acute brain injury: a brief review.International journal of inflammation · 2010Article
- C5a promotes migration, proliferation, and vessel formation in endothelial cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- C5a alters blood-brain barrier integrity in experimental lupus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The complement system is well represented in the central nervous system. Glial cells and neurons produce or express all of the activation and regulatory proteins and the C3a/C5a receptors. Inhibition of complement activation is protective in experimental allergic encephalomyelitis, the animal model for multiple sclerosis, suggesting possible therapeutic approaches for human disease. New findings indicate that the C3a/C5a receptors are widely expressed in neurons and may modulate neuronal function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.