ReviewClinical reviews in allergy & immunology2002
Autoimmune mechanisms as the basis for human peripartum cardiomyopathy.
Review in Clinical reviews in allergy & immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 189 citations in OpenAlex.
- The 2010 Canadian Cardiovascular Society guidelines for the diagnosis and management of heart failure update: Heart failure in ethnic minority populations, heart failure and pregnancy, disease management, and quality improvement/assurance programs.The Canadian journal of cardiology · 2010Guideline
- Pregnancy precipitates metabolic imbalance and accelerates death in an animal model of mitochondrial cardiomyopathy.Molecular metabolism · 2026Article
- Cardiovascular complications of pregnancy.The Journal of clinical investigation · 2026Review
- Caring for Two: Management of the Critically Ill Cardiac Patient During Pregnancy.JACC. Advances · 2025Review
- Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine.Nature reviews. Cardiology · 2025Review
- Cathepsin-D and outcomes in peripartum cardiomyopathy: Results from IPAC.American heart journal plus : cardiology research and practice · 2025Article
- Race, hypertensive disorders of pregnancy and outcomes in peripartum cardiomyopathy.American heart journal · 2024Article
- Postpartum dilated cardiomyopathy and antiphospholipid syndrome: A rare association revealed by a pulmonary embolism (case report).Radiology case reports · 2024Article
- Serum Proteomic Analysis of Peripartum Cardiomyopathy Reveals Distinctive Dysregulation of Inflammatory and Cholesterol Metabolism Pathways.JACC. Heart failure · 2023Article
- Peripartum Cardiomyopathy: Risks Diagnosis and Management.Journal of multidisciplinary healthcare · 2023Review
- Arrhythmias and Heart Failure in Pregnancy: A Dialogue on Multidisciplinary Collaboration.Journal of cardiovascular development and disease · 2022Review
- Peripartum cardiomyopathy.Heart failure reviews · 2021Review
- Cardiovascular adverse events in pregnancy: A global perspective.Global cardiology science & practice · 2021Review
- Left ventricular function recovery in peripartum cardiomyopathy: a cardiovascular magnetic resonance study by myocardial T1 and T2 mapping.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy.JACC. Basic to translational science · 2019Article
- The Use of Bromocriptine for Peripartum Cardiomyopathy after Twin Delivery via Oocyte Donation.Internal medicine (Tokyo, Japan) · 2019Article
- Peripartum Cardiomyopathy: an Update.Current heart failure reports · 2018Review
- Peripartum women with dyspnea in the emergency department: Is it peripartum cardiomyopathy?Medicine · 2018Observational
- Anesthetic Treatment of Cardiac Disease During Pregnancy.Current treatment options in cardiovascular medicine · 2018Review
- Two potentially lethal conditions of probable immune origin occurring in a pregnant woman: a case report.Journal of medical case reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The etiology and mechanisms of pathogenesis of human peripartum cardiomyopathy (PPCM) remain unknown. The incidence and prevalence of this disease is rare in some parts of the world and more common in others. The purpose of this review is to summarize our current knowledge of the factors that have been entertained which may contribute to the pathogenesis of PPCM with special emphasis on more recent data from our laboratory that provide support to the view that this disease is an autoimmune disease with multiple contributing factors and effector mechanisms. This is supported by the fact that sera from PPCM patients contain high titers of auto-antibodies against normal human cardiac tissue proteins of 37, 33, and 25 kD that was not present in the sera of patients with idiopathic cardiomyopathy (IDCM), indicating for the first time that PPCM is distinct from IDCM. In addition to the autoantibodies, the PBMC's from PPCM patients demonstrate a heightened level of fetal microchimerism, an abnormal cytokine profile, decreased levels of CD4+ CD25lo regulatory T cells, and a significant reduction in the plasma levels of progesterone, estradiol and relaxin in PPCM patients as compared with other normal pregnant non-PPCM patients. A potential role for reduced plasma levels of selenium in the pathogenesis of select PPCM patients was also noted. These findings for the first time suggest that such abnormalities may in concert lead to the initiation and perpetuation of an autoimmune process, which leads to cardiac failure and disease. Identification of the precise nature of the cardiac tissue autoantigens (currently in progress) will pave the way for the delineation of mechanism of this autoimmune disease. A working model for the pathogenesis of this disease is also described herein.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.