ArticleJournal of neurovirology2002
Epstein-Barr virus DNA load in cerebrospinal fluid and plasma of patients with AIDS-related lymphoma.
Article in Journal of neurovirology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 75 citations in OpenAlex.
- Lymphoma diagnosis and plasma Epstein-Barr virus load during vicriviroc therapy: results of the AIDS Clinical Trials Group A5211.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Trial
- Epstein-Barr Virus Detection in the Central Nervous System of HIV-Infected Patients.Pathogens (Basel, Switzerland) · 2022Review
- Metagenomic next-generation sequencing for identification of central nervous system pathogens in HIV-infected patients.Frontiers in microbiology · 2022Article
- An Unusual Case of CMV/EBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient.Case reports in infectious diseases · 2018Article
- A Rare Case of Three Distinct Epstein-Barr Virus Associated Lymphoproliferative Disorders Over Sixteen Years of Human Immunodeficiency Virus Infection.Hematology reports · 2017Article
- Primary brain lymphomas after kidney transplantation: an under-recognized problem?Journal of nephrology · 2014Article
- Critical care of persons infected with the human immunodeficiency virus.Clinics in chest medicine · 2013Review
- Use of staged molecular analysis to determine causes of unexplained central nervous system infections.Emerging infectious diseases · 2013Article
- Application of molecular diagnostic techniques for viral testing.The open virology journal · 2012Article
- Measurement of Epstein-Barr virus DNA load using a novel quantification standard containing two EBV DNA targets and SYBR Green I dye.Virology journal · 2010Article
- Spectrum of intracranial parenchymal lesions in patients with human immunodeficiency virus infection in the Republic of Korea.Journal of Korean medical science · 2010Article
- Neurologic presentations of AIDS.Neurologic clinics · 2010Review
- Biology and treatment of primary central nervous system lymphoma.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2009Review
- Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain.The Journal of experimental medicine · 2007Article
- Validation of Roche LightCycler Epstein-Barr virus quantification reagents in a clinical laboratory setting.The Journal of molecular diagnostics : JMD · 2006Article
- Real-time PCR in clinical microbiology: applications for routine laboratory testing.Clinical microbiology reviews · 2006Review
- Comparison of commercial real-time PCR assays for quantification of Epstein-Barr virus DNA.Journal of clinical microbiology · 2005Article
- Molecular methods for diagnosis of viral encephalitis.Clinical microbiology reviews · 2004Review
- Molecular analysis of cerebrospinal fluid in viral diseases of the central nervous system.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detection of Epstein-Barr virus (EBV) DNA in the cerebrospinal fluid (CSF) is associated with acquired immunodeficiency syndrome (AIDS)-related brain lymphoma. Real-time polymerase chain reaction (PCR) was performed to quantify EBV DNA in CSF and plasma from 42 patients with AIDS-related non-Hodgkin's lymphoma (NHL). Twenty patients had primary central nervous system lymphoma (PCNSL) and 22 systemic NHL, including 12 with central nervous system involvement (CNS-NHL). As controls, 16 HIV-infected patients with other CNS disorders were examined. EBV DNA was detected in the CSF from 16/20 (80%) patients with PCNSL, 7/22 (32%) with systemic NHL, 8/12 (67%) with CNS-NHL, and 2/16 (13%) of the controls. The viral EBV DNA levels were significantly higher in the CSF from patients with PCNSL or CNS-NHL compared to patients with systemic NHL or controls. EBV DNA was detected in plasma from 5/16 (31%) patients with PCNSL, 9/16 (56%) with systemic NHL, 4/9 (44%) with CNS-NHL, and 4/15 (27%) controls. No difference in plasma viral load was found between patient groups. From the patients with CNS-NHL, plasma samples drawn prior to CNS involvement contained significantly higher EBV DNA levels than those from systemic NHL patients without subsequent CNS involvement. EBV DNA levels in the CSF, but not in plasma, from patients treated with antiherpes drugs were significantly lower than in untreated patients. High CSF EBV DNA levels were found in HIV-associated brain lymphomas and the viral load can be clinically useful. High plasma EBV DNA levels might predict CNS involvement in systemic NHL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.