ArticleOncogene2002
Involvement of nectin in the localization of junctional adhesion molecule at tight junctions.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 123 citations in OpenAlex.
- Disruption of thrombospondin 1/2-integrin β1 axis impairs cell adhesion and tumor growth in intrahepatic cholangiocarcinoma.Cell death discovery · 2026Article
- Afadin loss induces breast cancer metastasis through destabilisation of E-cadherin to F-actin linkage.The Journal of pathology · 2025Article
- Junctional Adhesion Molecules: Potential Proteins in Atherosclerosis.Frontiers in cardiovascular medicine · 2022Review
- How cells tell up from down and stick together to construct multicellular tissues - interplay between apicobasal polarity and cell-cell adhesion.Journal of cell science · 2021Review
- The multifarious regulation of the apical junctional complex.Open biology · 2020Review
- Coordinated transient interaction of ZO-1 and afadin is required for pedestal maturation induced by EspF from enteropathogenic Escherichia coli.MicrobiologyOpen · 2019Article
- Implications of AMPK in the Formation of Epithelial Tight Junctions.International journal of molecular sciences · 2018Review
- Afadin Downregulation byFrontiers in microbiology · 2018Article
- Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey.PloS one · 2018Article
- Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Tight junctions: from simple barriers to multifunctional molecular gates.Nature reviews. Molecular cell biology · 2016Review
- Serum nectin-2 levels are diagnostic and prognostic in patients with colorectal carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Article
- Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Article
- "You Shall Not Pass"-tight junctions of the blood brain barrier.Frontiers in neuroscience · 2014Review
- Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers.Molecular cancer · 2013Article
- De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.Development (Cambridge, England) · 2013Article
- Article
- Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "Yin" and "Yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2.International review of cell and molecular biology · 2013Review
- Sticky situations: recent advances in control of cell adhesion during neuronal migration.Current opinion in neurobiology · 2012Review
- Membrane palmitoylated proteins regulate trafficking and processing of nectins.European journal of cell biology · 2011Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Junctional adhesion molecule (JAM) is a Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which localizes at tight junctions (TJs). Claudin is a key cell-cell adhesion molecule that forms TJ strands at TJs. JAM is associated with claudin through their cytoplasmic tail-binding protein, ZO-1. JAM is furthermore associated with Par-3, a cell polarity protein which forms a ternary complex with Par-6 and atypical protein kinase C. Nectin is another Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which localizes at adherens junctions (AJs). Nectin is associated with E-cadherin through their respective cytoplasmic tail-binding proteins, afadin and catenins, and involved in the formation of AJs cooperatively with E-cadherin. We show here that nectin is furthermore involved in the localization of JAM at TJs. During the formation of the junctional complex consisting of AJs and TJs in Madin-Darby canine kidney (MDCK) cells, JAM was recruited to the nectin-based cell-cell adhesion sites. This recruitment of JAM was inhibited by nectin inhibitors, which inhibited the trans-interaction of nectin. Microbeads coated with the extracellular fragment of nectin, that interacted with cellular nectin, also recruited JAM to the bead-MDCK cell contact sites. Furthermore, when cadherin-deficient L fibroblasts stably expressing both exogenous JAM and nectin (nectin-JAM-L cells) were co-cultured with L fibroblasts expressing only nectin (nectin-L cells), JAM was concentrated at the cell-cell adhesion sites between nectin-JAM-L and nectin-L cells without the trans-interaction of JAM. Analyses of the localization and immunoprecipitation of JAM revealed that it was associated with nectin through afadin and ZO-1. These results suggest that nectin has a role in the localization of JAM at TJs in the process of the formation of the junctional complex in epithelial cells.
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